Effects of striatal or accumbens lesions on the amphetamine-induced abolition of latent inhibition
Φόρτωση...
Ημερομηνία
Συγγραφείς
Konstandi, M.
Kafetzopoulos, E.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Pharmacol Biochem Behav
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
In this study, we tested the effects of nucleus accumbens or corpus striatum lesions on the abolition of latent inhibition induced by d-amphetamine. In the latent inhibition paradigm, animals learn to ignore a repeatedly presented nonreinforced stimulus. In this paradigm, the repeated nonreinforced preexposure to a stimulus retards subsequent conditioning to that stimulus. Pharmacological manipulations that enhance the dopaminergic function (e.g., d-amphetamine) abolish this ability to ignore an irrelevant stimulus. Previous studies have revealed a major role of the nucleus accumbens in the d-amphetamine-induced abolition of latent inhibition because intraacumbens injections of the drug mimic its systemic effects. The results of this study, however, revealed a significant increase in the disruption of latent inhibition by d-amphetamine between corpus striatum-lesioned and sham-operated rats, but a marginal difference between nucleus accumbens lesioned and sham-operated rats, which had been preexposed to the stimulus. These findings indicate that the corpus striatum plays also a major role in the disruption of latent inhibition by d-amphetamine. It seems, therefore, that the nucleus accumbens and corpus striatum may represent a functionally common system regarding the expression of latent inhibition, although different experimental manipulation can favor the one structure over the other, reflecting probably their complex function.
Περιγραφή
Λέξεις-κλειδιά
Animals, Conditioning, Operant/*drug effects, Corpus Striatum/anatomy & histology/drug effects/*physiology, Dextroamphetamine/*pharmacology, Ibotenic Acid/administration & dosage/pharmacology, Injections, Male, Nucleus Accumbens/anatomy & histology/drug effects/*physiology, Rats, Rats, Wistar
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/8469686
http://ac.els-cdn.com/009130579390001A/1-s2.0-009130579390001A-main.pdf?_tid=65dfaac27896c72c5934120027c1ec3c&acdnat=1332759712_ead47b7352d9ec19b5d675ea902830c6
http://ac.els-cdn.com/009130579390001A/1-s2.0-009130579390001A-main.pdf?_tid=65dfaac27896c72c5934120027c1ec3c&acdnat=1332759712_ead47b7352d9ec19b5d675ea902830c6
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής