Effects of striatal or accumbens lesions on the amphetamine-induced abolition of latent inhibition
| dc.contributor.author | Konstandi, M. | en |
| dc.contributor.author | Kafetzopoulos, E. | en |
| dc.date.accessioned | 2015-11-24T19:20:33Z | |
| dc.date.available | 2015-11-24T19:20:33Z | |
| dc.identifier.issn | 0091-3057 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/22048 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Conditioning, Operant/*drug effects | en |
| dc.subject | Corpus Striatum/anatomy & histology/drug effects/*physiology | en |
| dc.subject | Dextroamphetamine/*pharmacology | en |
| dc.subject | Ibotenic Acid/administration & dosage/pharmacology | en |
| dc.subject | Injections | en |
| dc.subject | Male | en |
| dc.subject | Nucleus Accumbens/anatomy & histology/drug effects/*physiology | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Wistar | en |
| dc.title | Effects of striatal or accumbens lesions on the amphetamine-induced abolition of latent inhibition | en |
| heal.abstract | In this study, we tested the effects of nucleus accumbens or corpus striatum lesions on the abolition of latent inhibition induced by d-amphetamine. In the latent inhibition paradigm, animals learn to ignore a repeatedly presented nonreinforced stimulus. In this paradigm, the repeated nonreinforced preexposure to a stimulus retards subsequent conditioning to that stimulus. Pharmacological manipulations that enhance the dopaminergic function (e.g., d-amphetamine) abolish this ability to ignore an irrelevant stimulus. Previous studies have revealed a major role of the nucleus accumbens in the d-amphetamine-induced abolition of latent inhibition because intraacumbens injections of the drug mimic its systemic effects. The results of this study, however, revealed a significant increase in the disruption of latent inhibition by d-amphetamine between corpus striatum-lesioned and sham-operated rats, but a marginal difference between nucleus accumbens lesioned and sham-operated rats, which had been preexposed to the stimulus. These findings indicate that the corpus striatum plays also a major role in the disruption of latent inhibition by d-amphetamine. It seems, therefore, that the nucleus accumbens and corpus striatum may represent a functionally common system regarding the expression of latent inhibition, although different experimental manipulation can favor the one structure over the other, reflecting probably their complex function. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/8469686 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/009130579390001A/1-s2.0-009130579390001A-main.pdf?_tid=65dfaac27896c72c5934120027c1ec3c&acdnat=1332759712_ead47b7352d9ec19b5d675ea902830c6 | - |
| heal.journalName | Pharmacol Biochem Behav | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 1993 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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