Influence of nutritional factors on bone collagen fibrils in ovariectomized rats
Abstract
Type
Type of the conference item
Journal type
peer-reviewed
Educational material type
Conference Name
Journal name
Bone
Book name
Book series
Book edition
Alternative title / Subtitle
Description
The influence of both vitamin D(3) and Ca:P ratio on bone collagen fibrils was investigated in ovariectomized rats. Six weeks after ovariectomy the rats were maintained for 80 days with diets containing vitamin D(3) and calcium supplementation. Age-matched ovariectomized animals were fed a normal diet. When vitamin D(3) was increased in the diet, although no effect in fibril organization was observed in relation to that from ovariectomized rats with the normal diet, a highly significant effect in fibril diameter was detected. When the calcium:phosphorus (Ca:P) ratio was increased from 1:1 to 2:1 (without vitamin D(3) supplementation) both structural fiber parameters were significantly affected. The results were closer to normal (i.e., collagen fibrils from animals without ovariectomy) when vitamin D(3) and Ca:P ratios were combined.
Description
Keywords
*Animal Nutritional Physiological Phenomena, Animals, Bone and Bones/*metabolism/ultrastructure, Collagen/*metabolism, Female, Microscopy, Electron, Ovariectomy, Rats, Rats, Wistar, Vitamin D/administration & dosage
Subject classification
Citation
Link
http://www.ncbi.nlm.nih.gov/pubmed/11062349
http://ac.els-cdn.com/S8756328200003823/1-s2.0-S8756328200003823-main.pdf?_tid=5352407113f810b51bc76fd71bfb9c7f&acdnat=1333106294_51c10dce52fe579450d0d5ef4c2b5632
http://ac.els-cdn.com/S8756328200003823/1-s2.0-S8756328200003823-main.pdf?_tid=5352407113f810b51bc76fd71bfb9c7f&acdnat=1333106294_51c10dce52fe579450d0d5ef4c2b5632
Language
en
Publishing department/division
Advisor name
Examining committee
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Institution and School/Department of submitter
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής