Concentration and relative distribution of low-density lipoprotein subfractions in patients with metabolic syndrome defined according to the National Cholesterol Education Program criteria
Φόρτωση...
Ημερομηνία
Συγγραφείς
Gazi, I.
Tsimihodimos, V.
Filippatos, T.
Bairaktari, E.
Tselepis, A. D.
Elisaf, M.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Metabolism-Clinical and Experimental
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
It has been proposed that the most common lipid abnormalities associated with the metabolic syndrome are elevated triglyceride and low high-density lipoprotein concentrations as well as the existence of small, dense low-density lipoprotein (LDL) particles. However, so far there are only limited clinical data concerning the distribution of LDL particles in patients with this syndrome. The aim of our study was to directly determine the concentration and relative distribution of LDL subfractions in patients with metabolic syndrome. One hundred seventy-five individuals were included. Patients with metabolic syndrome (n = 105) exhibited higher concentrations of dense LDL particles and lower mean LDL particle size than the control population (n = 70). Both of these parameters were significantly correlated with the number of components of metabolic syndrome. Multivariate analysis revealed that serum triglyceride concentration was the most important determinant of the presence of small, dense LDL particles. In conclusion, patients with metabolic syndrome exhibit higher concentrations of small, dense LDL subtractions than individuals who do not fulfill the criteria for the diagnosis of this syndrome. This increase is directly related to the number of components of metabolic syndrome and is mainly determined by the serum concentrations of triglycerides. (c) 2006 Elsevier Inc. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
ldl particle-size, coronary-artery disease, insulin-resistance, heart-disease, cardiovascular-disease, plasma triglyceride, risk, men, phenotype, atherosclerosis
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000238691700006
http://ac.els-cdn.com/S0026049506000771/1-s2.0-S0026049506000771-main.pdf?_tid=b8ed3f38763122e587115e76d8a729ca&acdnat=1333111215_613242271816b9e244a990cc4d050402
http://ac.els-cdn.com/S0026049506000771/1-s2.0-S0026049506000771-main.pdf?_tid=b8ed3f38763122e587115e76d8a729ca&acdnat=1333111215_613242271816b9e244a990cc4d050402
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας