Concentration and relative distribution of low-density lipoprotein subfractions in patients with metabolic syndrome defined according to the National Cholesterol Education Program criteria

Απλή σελίδα τεκμηρίου
dc.contributor.authorGazi, I.en
dc.contributor.authorTsimihodimos, V.en
dc.contributor.authorFilippatos, T.en
dc.contributor.authorBairaktari, E.en
dc.contributor.authorTselepis, A. D.en
dc.contributor.authorElisaf, M.en
dc.date.accessioned2015-11-24T16:54:32Z
dc.date.available2015-11-24T16:54:32Z
dc.identifier.issn0026-0495-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/10166
dc.rightsDefault Licence-
dc.subjectldl particle-sizeen
dc.subjectcoronary-artery diseaseen
dc.subjectinsulin-resistanceen
dc.subjectheart-diseaseen
dc.subjectcardiovascular-diseaseen
dc.subjectplasma triglycerideen
dc.subjectrisken
dc.subjectmenen
dc.subjectphenotypeen
dc.subjectatherosclerosisen
dc.titleConcentration and relative distribution of low-density lipoprotein subfractions in patients with metabolic syndrome defined according to the National Cholesterol Education Program criteriaen
heal.abstractIt has been proposed that the most common lipid abnormalities associated with the metabolic syndrome are elevated triglyceride and low high-density lipoprotein concentrations as well as the existence of small, dense low-density lipoprotein (LDL) particles. However, so far there are only limited clinical data concerning the distribution of LDL particles in patients with this syndrome. The aim of our study was to directly determine the concentration and relative distribution of LDL subfractions in patients with metabolic syndrome. One hundred seventy-five individuals were included. Patients with metabolic syndrome (n = 105) exhibited higher concentrations of dense LDL particles and lower mean LDL particle size than the control population (n = 70). Both of these parameters were significantly correlated with the number of components of metabolic syndrome. Multivariate analysis revealed that serum triglyceride concentration was the most important determinant of the presence of small, dense LDL particles. In conclusion, patients with metabolic syndrome exhibit higher concentrations of small, dense LDL subtractions than individuals who do not fulfill the criteria for the diagnosis of this syndrome. This increase is directly related to the number of components of metabolic syndrome and is mainly determined by the serum concentrations of triglycerides. (c) 2006 Elsevier Inc. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.metabol.2006.02.015-
heal.identifier.secondary<Go to ISI>://000238691700006-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0026049506000771/1-s2.0-S0026049506000771-main.pdf?_tid=b8ed3f38763122e587115e76d8a729ca&acdnat=1333111215_613242271816b9e244a990cc4d050402-
heal.journalNameMetabolism-Clinical and Experimentalen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ