Effects of adrenergic agents on rat peritoneal macrophages activated in vitro by acetylated low-density lipoprotein

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dc.contributor.authorKondomerkos, D. J.en
dc.contributor.authorKalamidas, S. A.en
dc.contributor.authorMichalis, L. K.en
dc.contributor.authorKanavaros, P.en
dc.date.accessioned2015-11-24T19:21:52Z
dc.date.available2015-11-24T19:21:52Z
dc.identifier.issn0344-0338-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22128
dc.rightsDefault Licence-
dc.subjectAcid Phosphatase/metabolismen
dc.subjectAdrenergic Agonists/*pharmacologyen
dc.subjectAdrenergic alpha-Agonists/pharmacologyen
dc.subjectAdrenergic beta-Agonists/pharmacologyen
dc.subjectAnimalsen
dc.subjectCell Shape/drug effectsen
dc.subjectCells, Cultureden
dc.subjectDobutamine/pharmacologyen
dc.subjectDose-Response Relationship, Drugen
dc.subjectEpinephrine/pharmacologyen
dc.subjectHydrogen Peroxide/metabolismen
dc.subjectIsoproterenol/pharmacologyen
dc.subjectLipopolysaccharides/pharmacologyen
dc.subjectLipoproteins, LDL/*pharmacologyen
dc.subjectMacrophage Activation/*drug effectsen
dc.subjectMacrophages, Peritoneal/cytology/*drug effects/metabolismen
dc.subjectNitric Oxide/metabolismen
dc.subjectNitrites/metabolismen
dc.subjectRatsen
dc.titleEffects of adrenergic agents on rat peritoneal macrophages activated in vitro by acetylated low-density lipoproteinen
heal.abstractMacrophages interact with modified lipoproteins and alter their functional status. In this study, the effects of the adrenergic agents adrenaline, isoproterenol, and dobutamine on macrophages activated with acetylated low-density lipoprotein were tested. The aim of this investigation was to determine whether adrenergic agents influence biologically significant functions of these cells in an in vitro model of macrophage-lipoprotein acute interaction. Rat peritoneal macrophages were incubated with acetylated low-density lipoprotein for 16 h, with or without adrenergic agents. Hydrogen peroxide and nitric oxide production and acid phosphatase activities in the supernatant and cell lysate were assayed. Adrenaline and isoproterenol inhibited the production of hydrogen peroxide, stimulated the production of nitric oxide, and increased the extracellular activity of acid phosphatase in the lipoprotein-activated cells. Dobutamine increased the extracellular, but decreased the intracellular acid phosphatase activity. Adrenaline and dobutamine also produced changes in the cell size and nuclear morphology of the macrophages. Macrophages are activated in vitro by acetylated low-density lipoprotein, and their functions and morphology are modified under the influence of adrenergic agents. Certain effects could be attributed to changes in cyclic AMP levels.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16047949-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0344033805000634/1-s2.0-S0344033805000634-main.pdf?_tid=ddc130743fa0eee7f1f56309d769371b&acdnat=1333090614_4484140746f42aa306b25bd04e822c06-
heal.journalNamePathol Res Practen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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