Comparison of the effects of simvastatin vs. rosuvastatin vs. simvastatin/ezetimibe on parameters of insulin resistance
Φόρτωση...
Ημερομηνία
Συγγραφείς
Moutzouri, E.
Liberopoulos, E.
Mikhailidis, D. P.
Kostapanos, M. S.
Kei, A. A.
Milionis, H.
Elisaf, M. S.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Int J Clin Pract
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Statin treatment may be associated with adverse effects on glucose metabolism. Whether this is a class effect is not known. In contrast, ezetimibe monotherapy may beneficially affect insulin sensitivity. OBJECTIVE: The aim of this study was to compare the effects of three different regimens of equivalent low-density lipoprotein cholesterol (LDL-C) lowering capacity on glucose metabolism. METHODS: A total of 153 patients (56 men), who had not achieved the LDL-C goal recommended by the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) despite a 3-month dietary and lifestyle intervention, were randomly allocated to receive open-label simvastatin 40 mg or rosuvastatin 10 mg or simvastatin/ezetimibe 10/10 mg for 12 weeks. The primary end point was changes in homeostasis model assessment of insulin resistance (HOMA-IR). Secondary endpoints consisted of changes in fasting insulin levels, fasting plasma glucose (FPG), glycosylated haemoglobin (HbA(1c) ), the HOMA of beta-cell function (HOMA-B) (a marker of basal insulin secretion by pancreatic beta-cells), LDL-C and high sensitivity C reactive protein (hsCRP). RESULTS: At week 12, all three treatment regimens were associated with significant increases in HOMA-IR and fasting insulin levels (p < 0.05 compared with baseline). No significant difference was observed between groups. No change in FPG, HbA(1c) and HOMA-B levels compared with baseline were noted in any of the three treatment groups. Changes in serum lipids and hsCRP were similar across groups. CONCLUSION: To the extent that simvastatin 40 mg, rosuvastatin 10 mg and simvastatin/ezetimibe 10/10 mg are associated with adverse effects on insulin resistance, they appear to be of the same magnitude.
Περιγραφή
Λέξεις-κλειδιά
Aged, Azetidines/administration & dosage/*adverse effects, Blood Glucose/drug effects/metabolism, Body Mass Index, Cholesterol, LDL/metabolism, Drug Combinations, Fasting/blood, Female, Fluorobenzenes/administration & dosage/*adverse effects, Homeostasis/drug effects, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage/*adverse, effects, Hypercholesterolemia/*drug therapy, Insulin Resistance/*physiology, Male, Medication Adherence, Middle Aged, Pyrimidines/administration & dosage/*adverse effects, Simvastatin/administration & dosage/*adverse effects, Sulfonamides/administration & dosage/*adverse effects, Treatment Outcome
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21995692
http://onlinelibrary.wiley.com/store/10.1111/j.1742-1241.2011.02779.x/asset/j.1742-1241.2011.02779.x.pdf?v=1&t=h0m94h2p&s=25f39563683e244c29452d6abce9c3daef94ec89
http://onlinelibrary.wiley.com/store/10.1111/j.1742-1241.2011.02779.x/asset/j.1742-1241.2011.02779.x.pdf?v=1&t=h0m94h2p&s=25f39563683e244c29452d6abce9c3daef94ec89
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής