Comparison of the effects of simvastatin vs. rosuvastatin vs. simvastatin/ezetimibe on parameters of insulin resistance

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dc.contributor.authorMoutzouri, E.en
dc.contributor.authorLiberopoulos, E.en
dc.contributor.authorMikhailidis, D. P.en
dc.contributor.authorKostapanos, M. S.en
dc.contributor.authorKei, A. A.en
dc.contributor.authorMilionis, H.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T19:28:22Z
dc.date.available2015-11-24T19:28:22Z
dc.identifier.issn1742-1241-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22891
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAzetidines/administration & dosage/*adverse effectsen
dc.subjectBlood Glucose/drug effects/metabolismen
dc.subjectBody Mass Indexen
dc.subjectCholesterol, LDL/metabolismen
dc.subjectDrug Combinationsen
dc.subjectFasting/blooden
dc.subjectFemaleen
dc.subjectFluorobenzenes/administration & dosage/*adverse effectsen
dc.subjectHomeostasis/drug effectsen
dc.subjectHumansen
dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage/*adverseen
dc.subjecteffectsen
dc.subjectHypercholesterolemia/*drug therapyen
dc.subjectInsulin Resistance/*physiologyen
dc.subjectMaleen
dc.subjectMedication Adherenceen
dc.subjectMiddle Ageden
dc.subjectPyrimidines/administration & dosage/*adverse effectsen
dc.subjectSimvastatin/administration & dosage/*adverse effectsen
dc.subjectSulfonamides/administration & dosage/*adverse effectsen
dc.subjectTreatment Outcomeen
dc.titleComparison of the effects of simvastatin vs. rosuvastatin vs. simvastatin/ezetimibe on parameters of insulin resistanceen
heal.abstractBACKGROUND: Statin treatment may be associated with adverse effects on glucose metabolism. Whether this is a class effect is not known. In contrast, ezetimibe monotherapy may beneficially affect insulin sensitivity. OBJECTIVE: The aim of this study was to compare the effects of three different regimens of equivalent low-density lipoprotein cholesterol (LDL-C) lowering capacity on glucose metabolism. METHODS: A total of 153 patients (56 men), who had not achieved the LDL-C goal recommended by the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) despite a 3-month dietary and lifestyle intervention, were randomly allocated to receive open-label simvastatin 40 mg or rosuvastatin 10 mg or simvastatin/ezetimibe 10/10 mg for 12 weeks. The primary end point was changes in homeostasis model assessment of insulin resistance (HOMA-IR). Secondary endpoints consisted of changes in fasting insulin levels, fasting plasma glucose (FPG), glycosylated haemoglobin (HbA(1c) ), the HOMA of beta-cell function (HOMA-B) (a marker of basal insulin secretion by pancreatic beta-cells), LDL-C and high sensitivity C reactive protein (hsCRP). RESULTS: At week 12, all three treatment regimens were associated with significant increases in HOMA-IR and fasting insulin levels (p < 0.05 compared with baseline). No significant difference was observed between groups. No change in FPG, HbA(1c) and HOMA-B levels compared with baseline were noted in any of the three treatment groups. Changes in serum lipids and hsCRP were similar across groups. CONCLUSION: To the extent that simvastatin 40 mg, rosuvastatin 10 mg and simvastatin/ezetimibe 10/10 mg are associated with adverse effects on insulin resistance, they appear to be of the same magnitude.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1742-1241.2011.02779.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21995692-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1742-1241.2011.02779.x/asset/j.1742-1241.2011.02779.x.pdf?v=1&t=h0m94h2p&s=25f39563683e244c29452d6abce9c3daef94ec89-
heal.journalNameInt J Clin Practen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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