The impact of renal function on the long-term clinical course of patients who underwent percutaneous coronary intervention
Φόρτωση...
Ημερομηνία
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Catheter Cardiovasc Interv
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVES: To determine the impact of the level of kidney function on the extended (>5 years) long-term clinical course of patients undergoing percutaneous coronary intervention (PCI). BACKGROUND: Chronic kidney disease (CKD) has been significantly associated with an increased in-hospital and 1-year mortality following PCI. METHODS: In this single-centre retrospective study, glomerular filtration rate (GFR) at baseline was estimated in 371 patients not on dialysis, who underwent successful PCI between mid-1995 and mid-1999. Baseline demographic and angiographic characteristics, and long-term major adverse cardiac events and symptoms were compared for patients with GFR > or =60 ml/min/1.73 m(2) (normal or mildly impaired renal function) and GFR > or = 60 ml/ min/1.73 m(2) (CKD). The independent effect of GFR, modelled both as a categorical and a continuous variable, on long-term clinical outcomes was also investigated using multivariate Cox regression analysis. RESULTS: Nine-year all-cause and cardiac mortality rates were significantly higher in the CKD group (45.9% vs. 10.6%, P < 0.0001 and 35.4% vs. 7.1%, P < 0.0001 respectively), while there was no difference in the repeat revascularization (P = 0.27) and nonfatal Q-wave myocardial infarction (P = 0.74) rates. Multivariate analysis demonstrated an independent impact of the level of GFR on long-term mortality; adjusted 9-year all-cause and cardiac mortality increased by approximately 16% and 11%, respectively for a decrease of GFR from 120 to 60 ml/min/1.73 m(2) and by approximately 14% and 9%, respectively for a decrease of GFR from 60 to 30 ml/min/1.73 m(2). CONCLUSIONS: The level of renal function is a strong determinant of long-term all-cause and cardiac mortality after successful PCI.
Περιγραφή
Λέξεις-κλειδιά
Aged, Angioplasty, Balloon, Coronary, Chi-Square Distribution, Coronary Angiography, Coronary Disease/*complications/mortality/*therapy, Female, Glomerular Filtration Rate, Humans, Kidney Failure, Chronic/*complications/mortality/*physiopathology, Male, Middle Aged, Proportional Hazards Models, Retrospective Studies, Risk Factors
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17253600
http://onlinelibrary.wiley.com/store/10.1002/ccd.20874/asset/20874_ftp.pdf?v=1&t=h0tf0qhg&s=0944826a0172cca34b319e80fe8dd5d95997b504
http://onlinelibrary.wiley.com/store/10.1002/ccd.20874/asset/20874_ftp.pdf?v=1&t=h0tf0qhg&s=0944826a0172cca34b319e80fe8dd5d95997b504
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής