The impact of renal function on the long-term clinical course of patients who underwent percutaneous coronary intervention

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dc.contributor.authorPapafaklis, M. I.en
dc.contributor.authorNaka, K. K.en
dc.contributor.authorPapamichael, N. D.en
dc.contributor.authorKolios, G.en
dc.contributor.authorSioros, L.en
dc.contributor.authorSclerou, V.en
dc.contributor.authorKatsouras, C. S.en
dc.contributor.authorMichalis, L. K.en
dc.date.accessioned2015-11-24T19:41:06Z
dc.date.available2015-11-24T19:41:06Z
dc.identifier.issn1522-1946-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24443
dc.rightsDefault Licence-
dc.subjectAgeden
dc.subjectAngioplasty, Balloon, Coronaryen
dc.subjectChi-Square Distributionen
dc.subjectCoronary Angiographyen
dc.subjectCoronary Disease/*complications/mortality/*therapyen
dc.subjectFemaleen
dc.subjectGlomerular Filtration Rateen
dc.subjectHumansen
dc.subjectKidney Failure, Chronic/*complications/mortality/*physiopathologyen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectProportional Hazards Modelsen
dc.subjectRetrospective Studiesen
dc.subjectRisk Factorsen
dc.titleThe impact of renal function on the long-term clinical course of patients who underwent percutaneous coronary interventionen
heal.abstractOBJECTIVES: To determine the impact of the level of kidney function on the extended (>5 years) long-term clinical course of patients undergoing percutaneous coronary intervention (PCI). BACKGROUND: Chronic kidney disease (CKD) has been significantly associated with an increased in-hospital and 1-year mortality following PCI. METHODS: In this single-centre retrospective study, glomerular filtration rate (GFR) at baseline was estimated in 371 patients not on dialysis, who underwent successful PCI between mid-1995 and mid-1999. Baseline demographic and angiographic characteristics, and long-term major adverse cardiac events and symptoms were compared for patients with GFR > or =60 ml/min/1.73 m(2) (normal or mildly impaired renal function) and GFR > or = 60 ml/ min/1.73 m(2) (CKD). The independent effect of GFR, modelled both as a categorical and a continuous variable, on long-term clinical outcomes was also investigated using multivariate Cox regression analysis. RESULTS: Nine-year all-cause and cardiac mortality rates were significantly higher in the CKD group (45.9% vs. 10.6%, P < 0.0001 and 35.4% vs. 7.1%, P < 0.0001 respectively), while there was no difference in the repeat revascularization (P = 0.27) and nonfatal Q-wave myocardial infarction (P = 0.74) rates. Multivariate analysis demonstrated an independent impact of the level of GFR on long-term mortality; adjusted 9-year all-cause and cardiac mortality increased by approximately 16% and 11%, respectively for a decrease of GFR from 120 to 60 ml/min/1.73 m(2) and by approximately 14% and 9%, respectively for a decrease of GFR from 60 to 30 ml/min/1.73 m(2). CONCLUSIONS: The level of renal function is a strong determinant of long-term all-cause and cardiac mortality after successful PCI.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1002/ccd.20874-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17253600-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/ccd.20874/asset/20874_ftp.pdf?v=1&t=h0tf0qhg&s=0944826a0172cca34b319e80fe8dd5d95997b504-
heal.journalNameCatheter Cardiovasc Interven
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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