Combined thrombophilic mutations in women with unexplained recurrent miscarriage
Φόρτωση...
Ημερομηνία
Συγγραφείς
Sotiriadis, A.
Vartholomatos, G.
Pavlou, M.
Kolaitis, N.
Dova, L.
Stefos, T.
Paraskevaidis, E.
Kalantaridou, S. N.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Am J Reprod Immunol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
PROBLEM: To compare the prevalence of five common thrombophilic polymorphisms and their combination in women with recurrent miscarriage and a control group. METHOD OF STUDY: Genomic analysis using polymerase chain reaction (PCR) was carried out in patients with two or more miscarriages and controls for Factor V Leiden, Factor V A1299H (HR2), Factor II G20210A, MTHFR C677T and MTHFR A1298C. Secondary analyses were made for number of miscarriages and gestational age at miscarriage. RESULTS: None the mutations was associated with significantly increased risk for recurrent miscarriage. The prevalence of combined thrombophilias (4/88 versus 2/88) did not increase the risk for miscarriage (OR 2.04, 95% CI 0.36-11.47). Although virtually all patients with thrombophilia had miscarriages<or=10 weeks, statistical significance was not reached due to the small size of the >10 weeks' subgroup. There was no difference in the distribution of Factor V Leiden (P=1.000), FII G20210A (P=0.652), and MTHFR C677T (P=0.869) between patients with two and three or more miscarriages, whereas MTHFR A1298C was more common among patients with two miscarriages (P=0.017). CONCLUSIONS: Combinations of the five thrombophilic mutations studied are an uncommon event with heterogeneous pattern and they do not significantly increase the risk for miscarriage.
Περιγραφή
Λέξεις-κλειδιά
Abortion, Habitual/blood/*genetics, Adult, Case-Control Studies, Factor V/genetics, Female, Humans, Methylenetetrahydrofolate Reductase (NADPH2)/genetics, *Mutation, Polymerase Chain Reaction, Pregnancy, Prothrombin/genetics, Thrombophilia/blood/*genetics
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17217367
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0897.2006.00454.x/asset/j.1600-0897.2006.00454.x.pdf?v=1&t=h0kwwn6t&s=eaf1f25cd7c724fde87d086888690108317647cb
http://onlinelibrary.wiley.com/store/10.1111/j.1600-0897.2006.00454.x/asset/j.1600-0897.2006.00454.x.pdf?v=1&t=h0kwwn6t&s=eaf1f25cd7c724fde87d086888690108317647cb
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής