Combined thrombophilic mutations in women with unexplained recurrent miscarriage

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dc.contributor.authorSotiriadis, A.en
dc.contributor.authorVartholomatos, G.en
dc.contributor.authorPavlou, M.en
dc.contributor.authorKolaitis, N.en
dc.contributor.authorDova, L.en
dc.contributor.authorStefos, T.en
dc.contributor.authorParaskevaidis, E.en
dc.contributor.authorKalantaridou, S. N.en
dc.date.accessioned2015-11-24T19:29:22Z
dc.date.available2015-11-24T19:29:22Z
dc.identifier.issn1046-7408-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/22967
dc.rightsDefault Licence-
dc.subjectAbortion, Habitual/blood/*geneticsen
dc.subjectAdulten
dc.subjectCase-Control Studiesen
dc.subjectFactor V/geneticsen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMethylenetetrahydrofolate Reductase (NADPH2)/geneticsen
dc.subject*Mutationen
dc.subjectPolymerase Chain Reactionen
dc.subjectPregnancyen
dc.subjectProthrombin/geneticsen
dc.subjectThrombophilia/blood/*geneticsen
dc.titleCombined thrombophilic mutations in women with unexplained recurrent miscarriageen
heal.abstractPROBLEM: To compare the prevalence of five common thrombophilic polymorphisms and their combination in women with recurrent miscarriage and a control group. METHOD OF STUDY: Genomic analysis using polymerase chain reaction (PCR) was carried out in patients with two or more miscarriages and controls for Factor V Leiden, Factor V A1299H (HR2), Factor II G20210A, MTHFR C677T and MTHFR A1298C. Secondary analyses were made for number of miscarriages and gestational age at miscarriage. RESULTS: None the mutations was associated with significantly increased risk for recurrent miscarriage. The prevalence of combined thrombophilias (4/88 versus 2/88) did not increase the risk for miscarriage (OR 2.04, 95% CI 0.36-11.47). Although virtually all patients with thrombophilia had miscarriages<or=10 weeks, statistical significance was not reached due to the small size of the >10 weeks' subgroup. There was no difference in the distribution of Factor V Leiden (P=1.000), FII G20210A (P=0.652), and MTHFR C677T (P=0.869) between patients with two and three or more miscarriages, whereas MTHFR A1298C was more common among patients with two miscarriages (P=0.017). CONCLUSIONS: Combinations of the five thrombophilic mutations studied are an uncommon event with heterogeneous pattern and they do not significantly increase the risk for miscarriage.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1600-0897.2006.00454.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17217367-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1600-0897.2006.00454.x/asset/j.1600-0897.2006.00454.x.pdf?v=1&t=h0kwwn6t&s=eaf1f25cd7c724fde87d086888690108317647cb-
heal.journalNameAm J Reprod Immunolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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