Randomised controlled trials in orthopaedic surgery and traumatology: overview of parameters and pitfalls
Loading...
Date
Authors
Soucacos, P. N.
Johnson, E. O.
Babis, G.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Type
Type of the conference item
Journal type
peer-reviewed
Educational material type
Conference Name
Journal name
Injury
Book name
Book series
Book edition
Alternative title / Subtitle
Description
There is a growing consensus that randomised controlled clinical trial (RCT) provide a secure basis for determining treatment effects. Prospective randomised clinical trials can be a powerful tool in medical science and evidence-based medicine. A well-defined study hypothesis, with a prospectively applied study design, blinded and randomised treatment allocation and assessment, with appropriate control groups can provide strong evidence in support of treatment decisions. However, the recent reviews of the medical literature indicate that the study design itself does not ensure the quality of science or useful and valid scientific data. Thus, regardless of the study design or level of evidence, it remains imperative for the physician and surgeon to critically evaluate a scientific report. Moreover, as randomisation, concealment of treatment allocation and blinding are difficult issues to resolve in orthopaedic surgery, future trials should focus on detailed and correct reporting of outcome measures.
Description
Keywords
Evidence-Based Medicine/methods, Humans, *Orthopedic Procedures, Outcome Assessment (Health Care)/methods, Randomized Controlled Trials as Topic/*methods, Research Design, Statistics as Topic, Wounds and Injuries/*surgery
Subject classification
Citation
Link
http://www.ncbi.nlm.nih.gov/pubmed/18533154
http://ac.els-cdn.com/S0020138308001071/1-s2.0-S0020138308001071-main.pdf?_tid=52e4bf3a2c3cb6b473ccb5ff5086af82&acdnat=1334047843_29ff69014fd66c439529a50a1718db1c
http://ac.els-cdn.com/S0020138308001071/1-s2.0-S0020138308001071-main.pdf?_tid=52e4bf3a2c3cb6b473ccb5ff5086af82&acdnat=1334047843_29ff69014fd66c439529a50a1718db1c
Language
en
Publishing department/division
Advisor name
Examining committee
General Description / Additional Comments
Institution and School/Department of submitter
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής