Do strong intramolecular hydrogen bonds persist in aqueous solution? Variable temperature gradient H-1, H-1-C-13 GE-HSQC and GE-HMBC NMR studies of flavonols and flavones in organic and aqueous mixtures
| dc.contributor.author | Exarchou, V. | en |
| dc.contributor.author | Troganis, A. | en |
| dc.contributor.author | Gerothanassis, I. P. | en |
| dc.contributor.author | Tsimidou, M. | en |
| dc.contributor.author | Boskou, D. | en |
| dc.date.accessioned | 2015-11-24T16:56:32Z | |
| dc.date.available | 2015-11-24T16:56:32Z | |
| dc.identifier.issn | 0040-4020 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/10450 | |
| dc.rights | Default Licence | - |
| dc.subject | intramolecular hydrogen bond | en |
| dc.subject | flavones | en |
| dc.subject | flavonols | en |
| dc.subject | ge-hsqc | en |
| dc.subject | ge-hmbc | en |
| dc.subject | nmr | en |
| dc.subject | nuclear-magnetic-resonance | en |
| dc.subject | chemical-shifts | en |
| dc.subject | hydroxyl protons | en |
| dc.subject | spectroscopy | en |
| dc.subject | quercetin | en |
| dc.title | Do strong intramolecular hydrogen bonds persist in aqueous solution? Variable temperature gradient H-1, H-1-C-13 GE-HSQC and GE-HMBC NMR studies of flavonols and flavones in organic and aqueous mixtures | en |
| heal.abstract | Intramolecular hydrogen bonds in crystals and in apolar media are well documented, however, the degree to which they persist in aqueous solution is controversial. We report here variable temperature gradient H-1, H-1-C-13 Gradient Enhanced Heteronuclear Single Quantum Correlation (GE-HSQC) and Gradient Enhanced Heteronuclear Multiple Bond Coherence (GE-HMBC) NMR studies of the flavonols quercetin and kaempferol and the flavone luteolin, in organic solvents and in mixtures of organic-aqueous solutions. It is demonstrated that the strong intramolecular hydrogen bond of the -CO(4) and -OH(5) moieties persists over a wide range of aqueous mixtures and, thus, provide a rare example of non-charged intramolecular hydrogen bonds, which is not overwhelmed by solvation with protic solvents, in particular in aqueous solution. (C) 2002 Elsevier Science Ltd. All rights reserved. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | Doi 10.1016/S0040-4020(02)00820-7 | - |
| heal.identifier.secondary | <Go to ISI>://000177916100006 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0040402002008207/1-s2.0-S0040402002008207-main.pdf?_tid=332a969e-3247-11e3-a528-00000aacb362&acdnat=1381476893_4e48f648142794b2383ef5d506e48e34 | - |
| heal.journalName | Tetrahedron | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2002 | - |
| heal.publisher | Elsevier | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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