Correlation of prostate specific antigen immunoactivity (IR-PSA) to other prognostic factors in female breast cancer
Loading...
Date
Authors
Griniatsos, J.
Diamantis, E.
Gioti, J.
Karyda, I.
Vassilopoulos, P. P.
Agnanti, N.
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Type
Type of the conference item
Journal type
peer-reviewed
Educational material type
Conference Name
Journal name
Anticancer Res
Book name
Book series
Book edition
Alternative title / Subtitle
Description
Recently, using an ultrasensitive time-resolved immuno-fluorometric assay, PSA immunoreactivity (IR-PSA) was found in breast tumor cytosols. We retrospectively studied 219 breast cancer patients, measuring IR-PSA in the tumor cytosols, and classified the breast cancers as either PSA positive or PSA negative based on an IR-PSA cut off level of 1 pg/mg. Multivariated analysis showed that IR-PSA is an independent favourable prognostic indicator for postmenopausal, node positive breast cancer patients. Additionally, IR-PSA correlates with reduced risk of relapse in ER+ve tumors and is negatively correlated with mutated p53, which increases the risk of relapse.
Description
Keywords
Adult, Aged, Breast Neoplasms/*metabolism/pathology, Female, Fluorometry, Humans, Middle Aged, Neoplasm Recurrence, Local, Prognosis, Prostate-Specific Antigen/*metabolism, Retrospective Studies, Tumor Suppressor Protein p53/metabolism
Subject classification
Citation
Link
http://www.ncbi.nlm.nih.gov/pubmed/9584052
Language
en
Publishing department/division
Advisor name
Examining committee
General Description / Additional Comments
Institution and School/Department of submitter
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής