Genetic and epigenetic risks of intracytoplasmic sperm injection method
Φόρτωση...
Ημερομηνία
Συγγραφείς
Georgiou, I.
Syrrou, M.
Pardalidis, N.
Karakitsios, K.
Mantzavinos, T.
Giotitsas, N.
Loutradis, D.
Dimitriadis, F.
Saito, M.
Miyagawa, I.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Asian J Androl
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Pregnancies achieved by assisted reproduction technologies, particularly by intracytoplasmic sperm injection (ICSI) procedures, are susceptible to genetic risks inherent to the male population treated with ICSI and additional risks inherent to this innovative procedure. The documented, as well as the theoretical, risks are discussed in the present review study. These risks mainly represent that consequences of the genetic abnormalities underlying male subfertility (or infertility) and might become stimulators for the development of novel approaches and applications in the treatment of infertility. In addition, risks with a polygenic background appearing at birth as congenital anomalies and other theoretical or stochastic risks are discussed. Recent data suggest that assisted reproductive technology might also affect epigenetic characteristics of the male gamete, the female gamete, or might have an impact on early embryogenesis. It might be also associated with an increased risk for genomic imprinting abnormalities.
Περιγραφή
Λέξεις-κλειδιά
Animals, Child, Preschool, Chromosome Aberrations, Chromosome Deletion, Congenital Abnormalities/genetics, *Epigenesis, Genetic, Female, Genomic Imprinting, HIV Infections/transmission, Haploidy, Humans, Infant, Infectious Disease Transmission, Vertical, Infertility, Male/*genetics, Klinefelter Syndrome/genetics, Male, Pregnancy, Preimplantation Diagnosis, Risk, Sex Chromosome Aberrations, Sperm Injections, Intracytoplasmic/*adverse effects, Spermatogenesis/genetics, Translocation, Genetic/genetics, X Chromosome/genetics, XYY Karyotype/genetics
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17111067
http://www.nature.com/aja/journal/v8/n6/pdf/aja2006105a.pdf
http://www.nature.com/aja/journal/v8/n6/pdf/aja2006105a.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής