Genetic and epigenetic risks of intracytoplasmic sperm injection method

dc.contributor.authorGeorgiou, I.en
dc.contributor.authorSyrrou, M.en
dc.contributor.authorPardalidis, N.en
dc.contributor.authorKarakitsios, K.en
dc.contributor.authorMantzavinos, T.en
dc.contributor.authorGiotitsas, N.en
dc.contributor.authorLoutradis, D.en
dc.contributor.authorDimitriadis, F.en
dc.contributor.authorSaito, M.en
dc.contributor.authorMiyagawa, I.en
dc.contributor.authorTzoumis, P.en
dc.contributor.authorSylakos, A.en
dc.contributor.authorKanakas, N.en
dc.contributor.authorMoustakareas, T.en
dc.contributor.authorBaltogiannis, D.en
dc.contributor.authorTouloupides, S.en
dc.contributor.authorGiannakis, D.en
dc.contributor.authorFatouros, M.en
dc.contributor.authorSofikitis, N.en
dc.date.accessioned2015-11-24T19:14:59Z
dc.date.available2015-11-24T19:14:59Z
dc.identifier.issn1008-682X-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21430
dc.rightsDefault Licence-
dc.subjectAnimalsen
dc.subjectChild, Preschoolen
dc.subjectChromosome Aberrationsen
dc.subjectChromosome Deletionen
dc.subjectCongenital Abnormalities/geneticsen
dc.subject*Epigenesis, Geneticen
dc.subjectFemaleen
dc.subjectGenomic Imprintingen
dc.subjectHIV Infections/transmissionen
dc.subjectHaploidyen
dc.subjectHumansen
dc.subjectInfanten
dc.subjectInfectious Disease Transmission, Verticalen
dc.subjectInfertility, Male/*geneticsen
dc.subjectKlinefelter Syndrome/geneticsen
dc.subjectMaleen
dc.subjectPregnancyen
dc.subjectPreimplantation Diagnosisen
dc.subjectRisken
dc.subjectSex Chromosome Aberrationsen
dc.subjectSperm Injections, Intracytoplasmic/*adverse effectsen
dc.subjectSpermatogenesis/geneticsen
dc.subjectTranslocation, Genetic/geneticsen
dc.subjectX Chromosome/geneticsen
dc.subjectXYY Karyotype/geneticsen
dc.titleGenetic and epigenetic risks of intracytoplasmic sperm injection methoden
heal.abstractPregnancies achieved by assisted reproduction technologies, particularly by intracytoplasmic sperm injection (ICSI) procedures, are susceptible to genetic risks inherent to the male population treated with ICSI and additional risks inherent to this innovative procedure. The documented, as well as the theoretical, risks are discussed in the present review study. These risks mainly represent that consequences of the genetic abnormalities underlying male subfertility (or infertility) and might become stimulators for the development of novel approaches and applications in the treatment of infertility. In addition, risks with a polygenic background appearing at birth as congenital anomalies and other theoretical or stochastic risks are discussed. Recent data suggest that assisted reproductive technology might also affect epigenetic characteristics of the male gamete, the female gamete, or might have an impact on early embryogenesis. It might be also associated with an increased risk for genomic imprinting abnormalities.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1745-7262.2006.00231.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17111067-
heal.identifier.secondaryhttp://www.nature.com/aja/journal/v8/n6/pdf/aja2006105a.pdf-
heal.journalNameAsian J Androlen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2006-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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