Physiological distribution of placental growth factor and soluble Flt-1 in early pregnancy
Φόρτωση...
Ημερομηνία
Συγγραφείς
Makrydimas, G.
Sotiriadis, A.
Savvidou, M. D.
Spencer, K.
Nicolaides, K. H.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Prenat Diagn
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: To examine the distribution of placental growth factor (PlGF), vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (sFlt-1) in maternal and embryonic fluid compartments in early pregnancy. METHOD: The concentrations of PlGF, VEGF and sFlt-1 were measured in coelomic fluid and maternal serum from 16 singleton pregnancies at 7.0-9.3 weeks. In six cases, amniotic fluid was also examined. RESULTS: The median concentration of PlGF was 14.1 (range 8.9-27.6) pg/mL in maternal serum, 13.9 (range 9.5-31.4) pg/mL in coelomic fluid and 8.9 (range 3.9-15.3) pg/mL in amniotic fluid. The concentration of PlGF increased between 7.0 and 9.3 weeks in maternal serum (p = 0.001) and decreased in coelomic and amniotic fluid (p = 0.001). The median concentration of sFlt-1 was 8561 (range 6724-10 673) pg/mL in coelomic fluid, 523 (range 244-986) pg/mL in maternal serum, 30 (range 12-83) pg/mL in amniotic fluid (p = 0.0001), and it did not change significantly with gestation. VEGF was undetectable in most of the samples, and therefore, no further analysis was performed. CONCLUSION: PlGF and sFlt-1 are present in the maternal and fetal fluid compartments in very early pregnancy, and their distribution is consistent with their site of production and the local conditions of transport.
Περιγραφή
Λέξεις-κλειδιά
Adult, Amniotic Fluid/*chemistry, Female, Fetus/*physiology, Gestational Age, Humans, Pregnancy, Pregnancy Proteins/blood/*physiology, Vascular Endothelial Growth Factor A/blood/*physiology, Vascular Endothelial Growth Factor Receptor-1/*blood
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/18264952
http://onlinelibrary.wiley.com/store/10.1002/pd.1916/asset/1916_ftp.pdf?v=1&t=h0l48jfu&s=7575bd53de96a2c8f6076d84591fa3ee6ff096b5
http://onlinelibrary.wiley.com/store/10.1002/pd.1916/asset/1916_ftp.pdf?v=1&t=h0l48jfu&s=7575bd53de96a2c8f6076d84591fa3ee6ff096b5
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής