Physiological distribution of placental growth factor and soluble Flt-1 in early pregnancy
| dc.contributor.author | Makrydimas, G. | en |
| dc.contributor.author | Sotiriadis, A. | en |
| dc.contributor.author | Savvidou, M. D. | en |
| dc.contributor.author | Spencer, K. | en |
| dc.contributor.author | Nicolaides, K. H. | en |
| dc.date.accessioned | 2015-11-24T18:58:30Z | |
| dc.date.available | 2015-11-24T18:58:30Z | |
| dc.identifier.issn | 0197-3851 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/19287 | |
| dc.rights | Default Licence | - |
| dc.subject | Adult | en |
| dc.subject | Amniotic Fluid/*chemistry | en |
| dc.subject | Female | en |
| dc.subject | Fetus/*physiology | en |
| dc.subject | Gestational Age | en |
| dc.subject | Humans | en |
| dc.subject | Pregnancy | en |
| dc.subject | Pregnancy Proteins/blood/*physiology | en |
| dc.subject | Vascular Endothelial Growth Factor A/blood/*physiology | en |
| dc.subject | Vascular Endothelial Growth Factor Receptor-1/*blood | en |
| dc.title | Physiological distribution of placental growth factor and soluble Flt-1 in early pregnancy | en |
| heal.abstract | OBJECTIVE: To examine the distribution of placental growth factor (PlGF), vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (sFlt-1) in maternal and embryonic fluid compartments in early pregnancy. METHOD: The concentrations of PlGF, VEGF and sFlt-1 were measured in coelomic fluid and maternal serum from 16 singleton pregnancies at 7.0-9.3 weeks. In six cases, amniotic fluid was also examined. RESULTS: The median concentration of PlGF was 14.1 (range 8.9-27.6) pg/mL in maternal serum, 13.9 (range 9.5-31.4) pg/mL in coelomic fluid and 8.9 (range 3.9-15.3) pg/mL in amniotic fluid. The concentration of PlGF increased between 7.0 and 9.3 weeks in maternal serum (p = 0.001) and decreased in coelomic and amniotic fluid (p = 0.001). The median concentration of sFlt-1 was 8561 (range 6724-10 673) pg/mL in coelomic fluid, 523 (range 244-986) pg/mL in maternal serum, 30 (range 12-83) pg/mL in amniotic fluid (p = 0.0001), and it did not change significantly with gestation. VEGF was undetectable in most of the samples, and therefore, no further analysis was performed. CONCLUSION: PlGF and sFlt-1 are present in the maternal and fetal fluid compartments in very early pregnancy, and their distribution is consistent with their site of production and the local conditions of transport. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.primary | 10.1002/pd.1916 | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/18264952 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1002/pd.1916/asset/1916_ftp.pdf?v=1&t=h0l48jfu&s=7575bd53de96a2c8f6076d84591fa3ee6ff096b5 | - |
| heal.journalName | Prenat Diagn | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2008 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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