Glycine maintains mitochondrial activity and bile composition following warm liver ischemia-reperfusion injury

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dc.contributor.authorSheth, H.en
dc.contributor.authorHafez, T.en
dc.contributor.authorGlantzounis, G. K.en
dc.contributor.authorSeifalian, A. M.en
dc.contributor.authorFuller, B.en
dc.contributor.authorDavidson, B. R.en
dc.date.accessioned2015-11-24T19:14:38Z
dc.date.available2015-11-24T19:14:38Z
dc.identifier.issn1440-1746-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21357
dc.rightsDefault Licence-
dc.subjectAlanine Transaminase/blooden
dc.subjectAnimalsen
dc.subjectAspartate Aminotransferases/blooden
dc.subjectBile/*metabolismen
dc.subjectDisease Models, Animalen
dc.subjectElectron Transport Complex IV/metabolismen
dc.subjectEnergy Metabolism/*drug effectsen
dc.subjectGlycine/administration & dosage/*pharmacologyen
dc.subjectHemodynamics/drug effectsen
dc.subjectInfusions, Intravenousen
dc.subjectInterleukin-8/blooden
dc.subjectLiver/*blood supply/*drug effects/metabolismen
dc.subjectLiver Circulation/drug effectsen
dc.subjectMicrocirculation/drug effectsen
dc.subjectMitochondria, Liver/*drug effects/metabolismen
dc.subjectOxidation-Reductionen
dc.subjectRabbitsen
dc.subjectReperfusion Injury/metabolism/physiopathology/*prevention & controlen
dc.subjectTime Factorsen
dc.subjectTumor Necrosis Factor-alpha/blooden
dc.subjectWarm Ischemia/*adverse effectsen
dc.titleGlycine maintains mitochondrial activity and bile composition following warm liver ischemia-reperfusion injuryen
heal.abstractBACKGROUND AND AIM: Experimental studies have shown protective effect by the non-essential amino acid glycine to liver ischemia-reperfusion (I/R) injury but the mechanism of action is unknown. METHODS: A rabbit model of hepatic lobar I/R was used. Three groups of animals (n=6) were studied: Sham group (laparotomy alone), ischemia reperfusion (I/R) group (1 h of liver lobar ischemia and 6 h of reperfusion), and a glycine I/R group (intravenous glycine 5 mg/kg prior to the I/R protocol). Systemic and hepatic hemodynamics, degree of liver injury (bile flow, transaminases), hepatic microcirculation, mitochondrial activity (redox state of cytochrome oxidase), bile composition and cytokines (tumor necrosis factor-alpha and interleukin-8) were measured during the experiment. RESULTS: Glycine administration increased portal blood flow, bile production, hepatic microcirculation and maintained cytochrome oxidase activity as compared with the I/R group during reperfusion. Glycine also reduced bile lactate surge and stimulated acetoacetate release in bile during reperfusion versus the I/R group. Cytokine levels (tumor necrosis factor-alpha, interleukin-8) and hepatocellular injury (aspartate aminotransferase and alanine aminotransferase) were significantly reduced by glycine administration. CONCLUSION: Intravenous glycine administration reduces liver warm I/R injury by reducing the systemic inflammatory response, and maintaining cellular energy production.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1111/j.1440-1746.2010.06323.x-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21175814-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1440-1746.2010.06323.x/asset/j.1440-1746.2010.06323.x.pdf?v=1&t=h0nqjx9j&s=dcfbfdac8d4a4d9771b28742e816dac668c68a0c-
heal.journalNameJ Gastroenterol Hepatolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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