High frequency of antibodies to Hantaan virus and hepatitis C virus in chronic haemodialysis patients. Coincidence or cross-reaction?
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Tsianos, E. V.
Dalekos, G. N.
Elisaf, M. S.
Zervou, E.
Siamopoulos, K. C.
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peer-reviewed
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J Intern Med
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OBJECTIVES: To address the question of whether there is any coincidence or cross-reaction between hepatitis C virus (HCV) and Hantaan virus (both RNA arboviruses), as well as to assess the frequency of antibodies to the above viruses amongst chronic haemodialysis patients in our region. DESIGN: Collection of serum samples from consecutive unselected chronic haemodialysis patients. SETTING: A tertiary referral center (University Hospital). SUBJECTS: One hundred and fourteen chronic haemodialysis patients were investigated for the presence of antibodies to HCV (anti-HCV) and Hantaan virus disease (anti-HVD). Eleven unselected non-haemodialysis patients with well-defined haemorrhagic fever with renal syndrome (HFRS) were also investigated for the anti-HCV antibodies comprising the disease control group. INTERVENTIONS: None. MAIN OUTCOME MEASURES: The utility of an anti-HVD positive test in chronic haemodialysis patients. RESULTS: Seventeen patients (14.9% 95% confidence interval [CI] 8.4-21.4%) were anti-HCV positive, whereas 15 (13.2%, 95% CI 6.9-19.3%) were anti-HVD positive. An anti-HCV positive test was confirmed by recombinant immunoblot assay (RIBA II) in 88.2%. The presence of anti-HCV antibodies was not associated with transfusions but with the longer duration of haemodialysis (62.8 +/- 29.8 vs. 31.2 +/- 29.3 months, P < 0.001). Anti-HVD antibodies were not associated with transfusions or with the duration of haemodialysis. Three patients were positive for both anti-HCV and anti-HVD antibodies. None of the 11 patients with well-defined HFRS had anti-HCV antibodies. CONCLUSIONS: Chronic haemodialysis patients are a high risk group for HCV infection in association with the duration of haemodialysis and, at least for our geographical area, these patients have to be examined for anti-HVD antibodies especially when a definite causative agent for chronic renal failure is not found. The HVD and HCV infection are not exceptional amongst haemodialysis patients in our region, whereas the possibility of a cross-reaction between these two RNA arboviruses is rather excluded as there was no evidence of HCV infection amongst the patients with well-defined HFRS.
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Adolescent, Adult, Aged, Antibodies, Viral/*blood, Cross Reactions, Female, Hantaan virus/*immunology, Hepacivirus/*immunology, Hepatitis Antibodies/blood, Humans, Male, Middle Aged, *Renal Dialysis
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http://www.ncbi.nlm.nih.gov/pubmed/8258753
http://onlinelibrary.wiley.com/store/10.1111/j.1365-2796.1993.tb01021.x/asset/j.1365-2796.1993.tb01021.x.pdf?v=1&t=h0ma4dcr&s=4cbbb6a47b9503838c419a691b501c7519c9cf3d
http://onlinelibrary.wiley.com/store/10.1111/j.1365-2796.1993.tb01021.x/asset/j.1365-2796.1993.tb01021.x.pdf?v=1&t=h0ma4dcr&s=4cbbb6a47b9503838c419a691b501c7519c9cf3d
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής