High frequency of antibodies to Hantaan virus and hepatitis C virus in chronic haemodialysis patients. Coincidence or cross-reaction?

Απλή σελίδα τεκμηρίου
dc.contributor.authorTsianos, E. V.en
dc.contributor.authorDalekos, G. N.en
dc.contributor.authorElisaf, M. S.en
dc.contributor.authorZervou, E.en
dc.contributor.authorSiamopoulos, K. C.en
dc.date.accessioned2015-11-24T19:13:49Z
dc.date.available2015-11-24T19:13:49Z
dc.identifier.issn0954-6820-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21230
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAntibodies, Viral/*blooden
dc.subjectCross Reactionsen
dc.subjectFemaleen
dc.subjectHantaan virus/*immunologyen
dc.subjectHepacivirus/*immunologyen
dc.subjectHepatitis Antibodies/blooden
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subject*Renal Dialysisen
dc.titleHigh frequency of antibodies to Hantaan virus and hepatitis C virus in chronic haemodialysis patients. Coincidence or cross-reaction?en
heal.abstractOBJECTIVES: To address the question of whether there is any coincidence or cross-reaction between hepatitis C virus (HCV) and Hantaan virus (both RNA arboviruses), as well as to assess the frequency of antibodies to the above viruses amongst chronic haemodialysis patients in our region. DESIGN: Collection of serum samples from consecutive unselected chronic haemodialysis patients. SETTING: A tertiary referral center (University Hospital). SUBJECTS: One hundred and fourteen chronic haemodialysis patients were investigated for the presence of antibodies to HCV (anti-HCV) and Hantaan virus disease (anti-HVD). Eleven unselected non-haemodialysis patients with well-defined haemorrhagic fever with renal syndrome (HFRS) were also investigated for the anti-HCV antibodies comprising the disease control group. INTERVENTIONS: None. MAIN OUTCOME MEASURES: The utility of an anti-HVD positive test in chronic haemodialysis patients. RESULTS: Seventeen patients (14.9% 95% confidence interval [CI] 8.4-21.4%) were anti-HCV positive, whereas 15 (13.2%, 95% CI 6.9-19.3%) were anti-HVD positive. An anti-HCV positive test was confirmed by recombinant immunoblot assay (RIBA II) in 88.2%. The presence of anti-HCV antibodies was not associated with transfusions but with the longer duration of haemodialysis (62.8 +/- 29.8 vs. 31.2 +/- 29.3 months, P < 0.001). Anti-HVD antibodies were not associated with transfusions or with the duration of haemodialysis. Three patients were positive for both anti-HCV and anti-HVD antibodies. None of the 11 patients with well-defined HFRS had anti-HCV antibodies. CONCLUSIONS: Chronic haemodialysis patients are a high risk group for HCV infection in association with the duration of haemodialysis and, at least for our geographical area, these patients have to be examined for anti-HVD antibodies especially when a definite causative agent for chronic renal failure is not found. The HVD and HCV infection are not exceptional amongst haemodialysis patients in our region, whereas the possibility of a cross-reaction between these two RNA arboviruses is rather excluded as there was no evidence of HCV infection amongst the patients with well-defined HFRS.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/8258753-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1111/j.1365-2796.1993.tb01021.x/asset/j.1365-2796.1993.tb01021.x.pdf?v=1&t=h0ma4dcr&s=4cbbb6a47b9503838c419a691b501c7519c9cf3d-
heal.journalNameJ Intern Meden
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1993-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

Αρχεία

Φάκελος/Πακέτο αδειών

Προβολή: 1 - 1 of 1
Μικρογραφία εικόνας
Ονομα:
license.txt
Μέγεθος:
1.74 KB
Μορφότυπο:
Item-specific license agreed upon to submission
Περιγραφή:
Κατεβάστε

Συλλογές

Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ