Recombinant human erythropoietin treatment of postpartum anemia. Preliminary results
Φόρτωση...
Ημερομηνία
Συγγραφείς
Makrydimas, G.
Lolis, D.
Lialios, G.
Tsiara, S.
Georgiou, I.
Bourantas, K. L.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Obstet Gynecol Reprod Biol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVES: The aim of this study was to investigate the efficacy of recombinant human erythropoietin (rHuEpo) in postpartum anemia. STUDY DESIGN: At the University Hospital of Ioannina, rHuEpo was administrated subcutaneously to twenty anemic women (hemoglobin [Hb]<10 g/dl), for 15 days following delivery; all were given iron and folic acid per os. Twenty other women (the control group) with postpartum anemia (Hb<10 g/dl), received only iron and folic acid. The Mann-Whitney U-test was used for the comparison of hematological indices between the two groups, on days 1, 3, 5, 10, 15 and 40 postdelivery. RESULTS: On day 3, reticulocyte counts were significantly higher in the women who received rHuEpo, as compared to the controls (P<0.05). The mean Hb value increased to >2 g/dl in the group undergoing rHuEpo therapy as compared to 0.7 g/dl in the control group on day 5 (P<0.05). Furthermore, two women in the control group required blood transfusions, while no transfusions were required by the rHuEpo group. CONCLUSIONS: rHuEpo administration is useful for a more rapid amelioration of hematological indices in women with postpartum anemia. Further, the dose given in this study was not associated with significant side-effects.
Περιγραφή
Λέξεις-κλειδιά
Adolescent, Adult, Anemia/blood/*drug therapy, Blood Transfusion, Erythropoietin/*therapeutic use, Female, Folic Acid/therapeutic use, Hemoglobins/analysis, Humans, Iron/therapeutic use, Length of Stay, Prospective Studies, Puerperal Disorders/*drug therapy, Recombinant Proteins, Reticulocyte Count
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/9846709
http://ac.els-cdn.com/S0301211598001584/1-s2.0-S0301211598001584-main.pdf?_tid=08a33865fdd93f38f030acc7546f0a96&acdnat=1337251416_3932dbb891def2f8009c5c1b7e9ef4dd
http://ac.els-cdn.com/S0301211598001584/1-s2.0-S0301211598001584-main.pdf?_tid=08a33865fdd93f38f030acc7546f0a96&acdnat=1337251416_3932dbb891def2f8009c5c1b7e9ef4dd
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής