NT-proBNP levels and diastolic dysfunction in beta-thalassaemia major patients
Φόρτωση...
Ημερομηνία
Συγγραφείς
Kremastinos, D. T.
Tsiapras, D. P.
Kostopoulou, A. G.
Hamodraka, E. S.
Chaidaroglou, A. S.
Kapsali, E. D.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Heart Fail
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: The early diagnosis and treatment of heart failure in beta-thalassaemic patients is related to survival. Iron alone or in combination with other factors causes diastolic dysfunction, which usually precedes systolic dysfunction. NT-proBNP is a sensitive biomarker of ventricular dysfunction. AIM: To evaluate NT-proBNP in non heart failure beta-thalassaemic patients. METHODS: Fifty-two beta-thalassaemia major patients (mean age: 27.2+/-12.5 years) with normal LV systolic function, underwent NT-proBNP measurement and a thorough Doppler-echocardiographic and pulsed tissue-Doppler study, 4 days following blood transfusion. Fifty-two age matched healthy controls were also studied. RESULTS: NT-proBNP and E/E' ratio were increased in thalassaemic patients compared with controls [(469+/-171 vs 262+/-51 pmol/l, p<0.001) and (10.8+/-4.0 vs 6.6+/-1.1, p<0.001)] and were well correlated (r: 0.54, p<0.01). Although NT-proBNP levels were increased in patients with higher E/E' ratios (E/E' <8: 354+/-119, 8-15: 516+/-177, >15: 565+/-114 pmol/l, ANOVA p: 0.002) this increase only became statistically significant in the 3rd decade of life, while E/E' ratio increased in the 4th decade. CONCLUSION: NT-proBNP increases in beta-thalassaemia major patients and is related to age and LV diastolic dysfunction. NT-proBNP appears to be an early biomarker of LV diastolic dysfunction, compared with the conventional Echo-Doppler indexes.
Περιγραφή
Λέξεις-κλειδιά
Adolescent, Adult, Age Factors, Analysis of Variance, Biological Markers/blood, Blood Flow Velocity, Case-Control Studies, Child, Child, Preschool, Diastole, Echocardiography, Doppler, Female, Ferritins/blood, Greece, Hemoglobins/metabolism, Humans, Linear Models, Male, Middle Aged, Natriuretic Peptide, Brain/*blood, Observer Variation, Peptide Fragments/*blood, Research Design, Stroke Volume, Ventricular Dysfunction,, Left/*blood/epidemiology/etiology/*physiopathology/ultrasonography, Ventricular Pressure, beta-Thalassemia/*blood/complications/epidemiology/*physiopathology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/17317307
http://eurjhf.oxfordjournals.org/content/9/5/531.full.pdf
http://eurjhf.oxfordjournals.org/content/9/5/531.full.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής