NT-proBNP levels and diastolic dysfunction in beta-thalassaemia major patients

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dc.contributor.authorKremastinos, D. T.en
dc.contributor.authorTsiapras, D. P.en
dc.contributor.authorKostopoulou, A. G.en
dc.contributor.authorHamodraka, E. S.en
dc.contributor.authorChaidaroglou, A. S.en
dc.contributor.authorKapsali, E. D.en
dc.date.accessioned2015-11-24T19:01:26Z
dc.date.available2015-11-24T19:01:26Z
dc.identifier.issn1388-9842-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/19690
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAdulten
dc.subjectAge Factorsen
dc.subjectAnalysis of Varianceen
dc.subjectBiological Markers/blooden
dc.subjectBlood Flow Velocityen
dc.subjectCase-Control Studiesen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectDiastoleen
dc.subjectEchocardiography, Doppleren
dc.subjectFemaleen
dc.subjectFerritins/blooden
dc.subjectGreeceen
dc.subjectHemoglobins/metabolismen
dc.subjectHumansen
dc.subjectLinear Modelsen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectNatriuretic Peptide, Brain/*blooden
dc.subjectObserver Variationen
dc.subjectPeptide Fragments/*blooden
dc.subjectResearch Designen
dc.subjectStroke Volumeen
dc.subjectVentricular Dysfunction,en
dc.subjectLeft/*blood/epidemiology/etiology/*physiopathology/ultrasonographyen
dc.subjectVentricular Pressureen
dc.subjectbeta-Thalassemia/*blood/complications/epidemiology/*physiopathologyen
dc.titleNT-proBNP levels and diastolic dysfunction in beta-thalassaemia major patientsen
heal.abstractBACKGROUND: The early diagnosis and treatment of heart failure in beta-thalassaemic patients is related to survival. Iron alone or in combination with other factors causes diastolic dysfunction, which usually precedes systolic dysfunction. NT-proBNP is a sensitive biomarker of ventricular dysfunction. AIM: To evaluate NT-proBNP in non heart failure beta-thalassaemic patients. METHODS: Fifty-two beta-thalassaemia major patients (mean age: 27.2+/-12.5 years) with normal LV systolic function, underwent NT-proBNP measurement and a thorough Doppler-echocardiographic and pulsed tissue-Doppler study, 4 days following blood transfusion. Fifty-two age matched healthy controls were also studied. RESULTS: NT-proBNP and E/E' ratio were increased in thalassaemic patients compared with controls [(469+/-171 vs 262+/-51 pmol/l, p<0.001) and (10.8+/-4.0 vs 6.6+/-1.1, p<0.001)] and were well correlated (r: 0.54, p<0.01). Although NT-proBNP levels were increased in patients with higher E/E' ratios (E/E' <8: 354+/-119, 8-15: 516+/-177, >15: 565+/-114 pmol/l, ANOVA p: 0.002) this increase only became statistically significant in the 3rd decade of life, while E/E' ratio increased in the 4th decade. CONCLUSION: NT-proBNP increases in beta-thalassaemia major patients and is related to age and LV diastolic dysfunction. NT-proBNP appears to be an early biomarker of LV diastolic dysfunction, compared with the conventional Echo-Doppler indexes.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1016/j.ejheart.2006.11.004-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/17317307-
heal.identifier.secondaryhttp://eurjhf.oxfordjournals.org/content/9/5/531.full.pdf-
heal.journalNameEur J Heart Failen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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