Epstein-Barr virus-associated high-grade anaplastic plasmacytoma in a renal transplant patient
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Authors
Papadaki, H. A.
Stefanaki, K.
Kanavaros, P.
Katonis, P.
Papastathi, H.
Valatas, W.
Stylianoy, K.
Eliopoulos, G. D.
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peer-reviewed
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Leuk Lymphoma
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Allograft transplant patients have an increased risk of developing polyclonal or monoclonal lymphoproliferative disorders, but high-grade anaplastic plasmacytomas are extremely rare in these patients. We present a renal transplant patient who developed multiple extramedullary high-grade anaplastic plasmacytomas in the oral cavity, the left maxillary antrum, the scalp, the thigh and the upper abdominal wall with no evidence of diffuse bone marrow infiltration. Epstein-Barr virus (EBV) mRNA transcripts were detected within the myeloma cells by in situ hybridization using EBER1-2 probes. Following discontinuation of immunosuppression applied, the patient was treated with a cyclophosphamide-prednisone regimen followed by local irradiation, and a complete remission was achieved within four weeks. We concluded that EBV-associated high-grade anaplastic plasmacytomas constitute one more type of post-transplant lymphoproliferative disorder, and that despite their characterization as highly malignant neoplasms, their clinical behavior is not always aggressive.
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Keywords
Herpesvirus 4, Human/*isolation & purification, Humans, In Situ Hybridization, Kidney Transplantation/*adverse effects, Lymphoproliferative Disorders/*etiology/pathology, Male, Middle Aged, Mouth Neoplasms/etiology/pathology/virology, Multiple Myeloma/*etiology/pathology/virology, Scalp, Skin Neoplasms/etiology/pathology/virology
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http://www.ncbi.nlm.nih.gov/pubmed/10674914
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en
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Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής