Changes in vascular function and structure in juvenile idiopathic arthritis
Φόρτωση...
Ημερομηνία
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Arthritis Care Res (Hoboken)
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
OBJECTIVE: Chronic inflammatory diseases in adults have been associated with increased cardiovascular risk and impaired vascular function. We aimed to assess the presence of early vascular dysfunction in patients with juvenile idiopathic arthritis (JIA) and investigate the role of inherent inflammatory process of JIA in vascular health. METHODS: Thirty patients with JIA (age range 7-18 years) were compared to 33 age- and sex-matched controls. Endothelial function (brachial artery flow-mediated dilation [FMD]), carotid intima-media thickness (IMT), and arterial stiffness were examined. Endothelial inflammation was assessed by intercellular adhesion molecule 1 (ICAM-1) and P-selectin measurements. RESULTS: Patients with JIA showed decreased FMD compared to controls (P = 0.001), independent of age (P = 0.9 among age subgroups). Baseline differences in erythrocyte sedimentation rate, ICAM-1, and glucose between the 2 groups accounted for the difference in FMD. The presence of systemic JIA was associated with greater IMT compared to patients with oligoarticular disease, polyarticular disease, or controls (P = 0.014, P = 0.069, and P = 0.046, respectively). The difference in IMT between systemic versus oligoarticular/polyarticular JIA was attributed to the following risk factors: age, body mass index, blood pressure, disease activity, and corticosteroids use. There were no differences in arterial stiffness indices between JIA patients and controls or between patients with systemic versus nonsystemic disease. CONCLUSION: Endothelial function is impaired in patients with JIA at a very young age, while IMT is increased only in the presence of systemic JIA. Vascular dysfunction may be partly attributed to the effects of disease-related characteristics (inflammation, disease activity, and medications).
Περιγραφή
Λέξεις-κλειδιά
Adolescent, Age Factors, Analysis of Variance, Arthritis, Juvenile, Rheumatoid/*complications/diagnosis/immunology/physiopathology, Biological Markers/blood, Brachial Artery/immunology/*physiopathology/ultrasonography, C-Reactive Protein/analysis, Carotid Artery, Common/immunology/*pathology/ultrasonography, Case-Control Studies, Child, Cross-Sectional Studies, Endothelium, Vascular/immunology/*physiopathology/ultrasonography, Female, Greece, Humans, Inflammation Mediators/blood, Intercellular Adhesion Molecule-1/blood, Linear Models, Male, Manometry, P-Selectin/blood, Risk Assessment, Risk Factors, Tunica Intima/immunology/*pathology/ultrasonography, Tunica Media/immunology/*pathology/ultrasonography, Ultrasonography, Doppler, Vascular Diseases/diagnosis/*etiology/immunology/physiopathology, *Vasodilation
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/21905249
http://onlinelibrary.wiley.com/store/10.1002/acr.20613/asset/20613_ftp.pdf?v=1&t=h0b40vud&s=34d67096c11d948e12e6087b354de9e0a3d532f2
http://onlinelibrary.wiley.com/store/10.1002/acr.20613/asset/20613_ftp.pdf?v=1&t=h0b40vud&s=34d67096c11d948e12e6087b354de9e0a3d532f2
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής