Changes in vascular function and structure in juvenile idiopathic arthritis

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dc.contributor.authorVlahos, A. P.en
dc.contributor.authorTheocharis, P.en
dc.contributor.authorBechlioulis, A.en
dc.contributor.authorNaka, K. K.en
dc.contributor.authorVakalis, K.en
dc.contributor.authorPapamichael, N. D.en
dc.contributor.authorAlfantaki, S.en
dc.contributor.authorGartzonika, K.en
dc.contributor.authorMavridis, A.en
dc.contributor.authorMichalis, L. K.en
dc.contributor.authorSiamopoulou, A.en
dc.date.accessioned2015-11-24T19:30:59Z
dc.date.available2015-11-24T19:30:59Z
dc.identifier.issn2151-4658-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/23189
dc.rightsDefault Licence-
dc.subjectAdolescenten
dc.subjectAge Factorsen
dc.subjectAnalysis of Varianceen
dc.subjectArthritis, Juvenileen
dc.subjectRheumatoid/*complications/diagnosis/immunology/physiopathologyen
dc.subjectBiological Markers/blooden
dc.subjectBrachial Artery/immunology/*physiopathology/ultrasonographyen
dc.subjectC-Reactive Protein/analysisen
dc.subjectCarotid Artery, Common/immunology/*pathology/ultrasonographyen
dc.subjectCase-Control Studiesen
dc.subjectChilden
dc.subjectCross-Sectional Studiesen
dc.subjectEndothelium, Vascular/immunology/*physiopathology/ultrasonographyen
dc.subjectFemaleen
dc.subjectGreeceen
dc.subjectHumansen
dc.subjectInflammation Mediators/blooden
dc.subjectIntercellular Adhesion Molecule-1/blooden
dc.subjectLinear Modelsen
dc.subjectMaleen
dc.subjectManometryen
dc.subjectP-Selectin/blooden
dc.subjectRisk Assessmenten
dc.subjectRisk Factorsen
dc.subjectTunica Intima/immunology/*pathology/ultrasonographyen
dc.subjectTunica Media/immunology/*pathology/ultrasonographyen
dc.subjectUltrasonography, Doppleren
dc.subjectVascular Diseases/diagnosis/*etiology/immunology/physiopathologyen
dc.subject*Vasodilationen
dc.titleChanges in vascular function and structure in juvenile idiopathic arthritisen
heal.abstractOBJECTIVE: Chronic inflammatory diseases in adults have been associated with increased cardiovascular risk and impaired vascular function. We aimed to assess the presence of early vascular dysfunction in patients with juvenile idiopathic arthritis (JIA) and investigate the role of inherent inflammatory process of JIA in vascular health. METHODS: Thirty patients with JIA (age range 7-18 years) were compared to 33 age- and sex-matched controls. Endothelial function (brachial artery flow-mediated dilation [FMD]), carotid intima-media thickness (IMT), and arterial stiffness were examined. Endothelial inflammation was assessed by intercellular adhesion molecule 1 (ICAM-1) and P-selectin measurements. RESULTS: Patients with JIA showed decreased FMD compared to controls (P = 0.001), independent of age (P = 0.9 among age subgroups). Baseline differences in erythrocyte sedimentation rate, ICAM-1, and glucose between the 2 groups accounted for the difference in FMD. The presence of systemic JIA was associated with greater IMT compared to patients with oligoarticular disease, polyarticular disease, or controls (P = 0.014, P = 0.069, and P = 0.046, respectively). The difference in IMT between systemic versus oligoarticular/polyarticular JIA was attributed to the following risk factors: age, body mass index, blood pressure, disease activity, and corticosteroids use. There were no differences in arterial stiffness indices between JIA patients and controls or between patients with systemic versus nonsystemic disease. CONCLUSION: Endothelial function is impaired in patients with JIA at a very young age, while IMT is increased only in the presence of systemic JIA. Vascular dysfunction may be partly attributed to the effects of disease-related characteristics (inflammation, disease activity, and medications).en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primary10.1002/acr.20613-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/21905249-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/acr.20613/asset/20613_ftp.pdf?v=1&t=h0b40vud&s=34d67096c11d948e12e6087b354de9e0a3d532f2-
heal.journalNameArthritis Care Res (Hoboken)en
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2011-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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