Synthesis, structural characterization and biological studies of novel mixed ligand Ag(I) complexes with triphenylphosphine and aspirin or salicylic acid
Φόρτωση...
Ημερομηνία
Συγγραφείς
Poyraz, M.
Banti, C. N.
Kourkoumelis, N.
Dokorou, V.
Manos, M. J.
Simcic, M.
Golic-Grdadolnik, S.
Mavromoustakos, T.
Giannoulis, A. D.
Verginadis, I. I.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Elsevier
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Inorganica Chimica Acta
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Two new mixed ligand silver(I) complexes of formulae {[Ag(tpp)(3)(asp)](dmf)} (1) (aspH = o-acetylsalicylic acid and tpp = triphenylphosphine) and [Ag(tpp)(2)(o-Hbza)] (2) (o-HbzaH = o-hydroxy-benzoic acid) were synthesized and characterized by elemental analyses, spectroscopic techniques and X-ray crystallography at ambient conditions. Three phosphorus and one carboxylic oxygen atoms from a de-protonated aspirin ligand in complex 1 and two phosphorus and two carboxylic oxygen atoms from a chelating o-Hbza anion in complex 2 form a tetrahedral geometry around Ag(I) ions in both complexes. Complexes 1 and 2 and the silver(I) nitrate, tpp, aspNa and o-HbzaH were tested for their in vitro cytotoxic activity against leiomyosarcoma cells (LMS), human breast adenocarcinoma cells (MCF-7) and normal human fetal lung fibroblasts (MRC-5) cells with Thiazolyl Blue Tetrazolium Bromide (MTT) assay. For both cell lines 1 and 2 were found to be more active than cisplatin. Additionally, 1 and 2 exhibit lower activity on cell growth proliferation of MRC-5 cells. The type of LMS cell death caused by 1 and 2 were evaluated in vitro by use of flow cytometry assay. The results show that at concentrations of 1.5 and 1.9 mu M of complex 1, 44.1% and 69.4%, respectively of LMS cells undergo programmed cell death (apoptosis). When LMS cells were treated with 1.6 and 2.3 mu M of 2, LMS cells death was by 29.6% and 81.3%, respectively apoptotic. Finally, the influence of the complexes 1 and 2, upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically and theoretically studied. The binding of 1 and 2 towards LOX was also investigated by Saturation Transfer Difference (STD) H-1 NMR experiments. (C) 2011 Elsevier B.V. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
bioinorganic chemistry, silver(i) complexes, aspirin, crystal structures, cytotoxic activity, std h-1 nmr, crystal-structure, silver(i) complexes, in-vitro, anticonvulsant activities, derivatives, organotin(iv), lipoxygenase, thioamides, dinuclear, gold(i)
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000293783900016
http://ac.els-cdn.com/S0020169311003896/1-s2.0-S0020169311003896-main.pdf?_tid=548a64a2-3636-11e3-a0e8-00000aacb361&acdnat=1381909452_a621d28f02a1aafbbf2f4030f480086b
http://ac.els-cdn.com/S0020169311003896/1-s2.0-S0020169311003896-main.pdf?_tid=548a64a2-3636-11e3-a0e8-00000aacb361&acdnat=1381909452_a621d28f02a1aafbbf2f4030f480086b
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας