Synthesis, structural characterization and biological studies of novel mixed ligand Ag(I) complexes with triphenylphosphine and aspirin or salicylic acid

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dc.contributor.authorPoyraz, M.en
dc.contributor.authorBanti, C. N.en
dc.contributor.authorKourkoumelis, N.en
dc.contributor.authorDokorou, V.en
dc.contributor.authorManos, M. J.en
dc.contributor.authorSimcic, M.en
dc.contributor.authorGolic-Grdadolnik, S.en
dc.contributor.authorMavromoustakos, T.en
dc.contributor.authorGiannoulis, A. D.en
dc.contributor.authorVerginadis, I. I.en
dc.contributor.authorCharalabopoulos, K.en
dc.contributor.authorHadjikakou, S. K.en
dc.date.accessioned2015-11-24T16:49:40Z
dc.date.available2015-11-24T16:49:40Z
dc.identifier.issn0020-1693-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9517
dc.rightsDefault Licence-
dc.subjectbioinorganic chemistryen
dc.subjectsilver(i) complexesen
dc.subjectaspirinen
dc.subjectcrystal structuresen
dc.subjectcytotoxic activityen
dc.subjectstd h-1 nmren
dc.subjectcrystal-structureen
dc.subjectsilver(i) complexesen
dc.subjectin-vitroen
dc.subjectanticonvulsant activitiesen
dc.subjectderivativesen
dc.subjectorganotin(iv)en
dc.subjectlipoxygenaseen
dc.subjectthioamidesen
dc.subjectdinuclearen
dc.subjectgold(i)en
dc.titleSynthesis, structural characterization and biological studies of novel mixed ligand Ag(I) complexes with triphenylphosphine and aspirin or salicylic aciden
heal.abstractTwo new mixed ligand silver(I) complexes of formulae {[Ag(tpp)(3)(asp)](dmf)} (1) (aspH = o-acetylsalicylic acid and tpp = triphenylphosphine) and [Ag(tpp)(2)(o-Hbza)] (2) (o-HbzaH = o-hydroxy-benzoic acid) were synthesized and characterized by elemental analyses, spectroscopic techniques and X-ray crystallography at ambient conditions. Three phosphorus and one carboxylic oxygen atoms from a de-protonated aspirin ligand in complex 1 and two phosphorus and two carboxylic oxygen atoms from a chelating o-Hbza anion in complex 2 form a tetrahedral geometry around Ag(I) ions in both complexes. Complexes 1 and 2 and the silver(I) nitrate, tpp, aspNa and o-HbzaH were tested for their in vitro cytotoxic activity against leiomyosarcoma cells (LMS), human breast adenocarcinoma cells (MCF-7) and normal human fetal lung fibroblasts (MRC-5) cells with Thiazolyl Blue Tetrazolium Bromide (MTT) assay. For both cell lines 1 and 2 were found to be more active than cisplatin. Additionally, 1 and 2 exhibit lower activity on cell growth proliferation of MRC-5 cells. The type of LMS cell death caused by 1 and 2 were evaluated in vitro by use of flow cytometry assay. The results show that at concentrations of 1.5 and 1.9 mu M of complex 1, 44.1% and 69.4%, respectively of LMS cells undergo programmed cell death (apoptosis). When LMS cells were treated with 1.6 and 2.3 mu M of 2, LMS cells death was by 29.6% and 81.3%, respectively apoptotic. Finally, the influence of the complexes 1 and 2, upon the catalytic peroxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX) was kinetically and theoretically studied. The binding of 1 and 2 towards LOX was also investigated by Saturation Transfer Difference (STD) H-1 NMR experiments. (C) 2011 Elsevier B.V. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.ica.2011.04.032-
heal.identifier.secondary<Go to ISI>://000293783900016-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0020169311003896/1-s2.0-S0020169311003896-main.pdf?_tid=548a64a2-3636-11e3-a0e8-00000aacb361&acdnat=1381909452_a621d28f02a1aafbbf2f4030f480086b-
heal.journalNameInorganica Chimica Actaen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2011-
heal.publisherElsevieren
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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