The impact of intravenous fat emulsion administration in acute lung injury
Φόρτωση...
Ημερομηνία
Συγγραφείς
Lekka, M. E.
Liokatis, S.
Nathanail, C.
Galani, V.
Nakos, G.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
American Thoracic Society
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Am J Respir Crit Care Med
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The aim of this study was to evaluate the effect of parenteral nutrition containing medium- and long-chain triglycerides on the function of the respiratory system and to investigate mechanisms involved in this process. We studied 13 patients with acute respiratory distress syndrome (ARDS), 8 receiving lipid and 5 placebo, and 6 without ARDS, receiving lipid. Bronchoalveolar lavage (BAL) was performed before and 1 hour after administration of lipid or placebo. In patients with ARDS, lipid administration resulted in deterioration of oxygenation (Pa-O2/Fi(O2): from 129 +/- 37 to 95 +/- 42), compliance of respiratory system (from 39.2 +/- 12 to 33.1 +/- 9.2 ml/cm H2O), and pulmonary vascular resistance (from 258 +/- 47 to 321 +/- 58 dyne.s.cm(-1)). In the BAL fluid of the same group, an increase in total protein and phospholipid concentrations, phospholipase activities, platelet-activating factor and neutrophils, as well as alterations in BAL lipid profile were observed. No significant changes were observed in the control or in the ARDS-Placebo groups. In conclusion, this study indicates that administration of medium- and long-chain triglycerides in patients with ARDS causes alterations in lung function and hemodynamics. Inflammatory cells, possibly activated by lipids, release phospholipase A(2) and platelet-activating factor, enhancing edema formation, inflammation, and surfactant alterations.
Περιγραφή
Λέξεις-κλειδιά
parenteral nutrition, medium-chain triglycericles/long-chain triglycerides, phospholipase a(2), platelet-activating factor-acetylhydrolase, platelet-activating factor, respiratory-distress-syndrome, platelet-activating-factor, pulmonary surfactant, gas-exchange, intralipid infusion, phospholipases a(2), permeability, proteins, ards, lysophosphatidylcholine
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000189249300019
http://ajrccm.atsjournals.org/content/169/5/638.full.pdf
http://ajrccm.atsjournals.org/content/169/5/638.full.pdf
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας