The impact of intravenous fat emulsion administration in acute lung injury
| dc.contributor.author | Lekka, M. E. | en |
| dc.contributor.author | Liokatis, S. | en |
| dc.contributor.author | Nathanail, C. | en |
| dc.contributor.author | Galani, V. | en |
| dc.contributor.author | Nakos, G. | en |
| dc.date.accessioned | 2015-11-24T16:50:43Z | |
| dc.date.available | 2015-11-24T16:50:43Z | |
| dc.identifier.issn | 1073-449X | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9634 | |
| dc.rights | Default Licence | - |
| dc.subject | parenteral nutrition | en |
| dc.subject | medium-chain triglycericles/long-chain triglycerides | en |
| dc.subject | phospholipase a(2) | en |
| dc.subject | platelet-activating factor-acetylhydrolase | en |
| dc.subject | platelet-activating factor | en |
| dc.subject | respiratory-distress-syndrome | en |
| dc.subject | platelet-activating-factor | en |
| dc.subject | pulmonary surfactant | en |
| dc.subject | gas-exchange | en |
| dc.subject | intralipid infusion | en |
| dc.subject | phospholipases a(2) | en |
| dc.subject | permeability | en |
| dc.subject | proteins | en |
| dc.subject | ards | en |
| dc.subject | lysophosphatidylcholine | en |
| dc.title | The impact of intravenous fat emulsion administration in acute lung injury | en |
| heal.abstract | The aim of this study was to evaluate the effect of parenteral nutrition containing medium- and long-chain triglycerides on the function of the respiratory system and to investigate mechanisms involved in this process. We studied 13 patients with acute respiratory distress syndrome (ARDS), 8 receiving lipid and 5 placebo, and 6 without ARDS, receiving lipid. Bronchoalveolar lavage (BAL) was performed before and 1 hour after administration of lipid or placebo. In patients with ARDS, lipid administration resulted in deterioration of oxygenation (Pa-O2/Fi(O2): from 129 +/- 37 to 95 +/- 42), compliance of respiratory system (from 39.2 +/- 12 to 33.1 +/- 9.2 ml/cm H2O), and pulmonary vascular resistance (from 258 +/- 47 to 321 +/- 58 dyne.s.cm(-1)). In the BAL fluid of the same group, an increase in total protein and phospholipid concentrations, phospholipase activities, platelet-activating factor and neutrophils, as well as alterations in BAL lipid profile were observed. No significant changes were observed in the control or in the ARDS-Placebo groups. In conclusion, this study indicates that administration of medium- and long-chain triglycerides in patients with ARDS causes alterations in lung function and hemodynamics. Inflammatory cells, possibly activated by lipids, release phospholipase A(2) and platelet-activating factor, enhancing edema formation, inflammation, and surfactant alterations. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | <Go to ISI>://000189249300019 | - |
| heal.identifier.secondary | http://ajrccm.atsjournals.org/content/169/5/638.full.pdf | - |
| heal.journalName | Am J Respir Crit Care Med | en |
| heal.journalType | peer reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2004 | - |
| heal.publisher | American Thoracic Society | en |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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