Immunohistochemical distribution of renal prostaglandin endoperoxide synthase and prostacyclin synthase: diminished endoperoxide synthase in the hepatorenal syndrome

dc.contributor.authorGovindarajan, S.en
dc.contributor.authorNast, C. C.en
dc.contributor.authorSmith, W. L.en
dc.contributor.authorKoyle, M. A.en
dc.contributor.authorDaskalopoulos, G.en
dc.contributor.authorZipser, R. D.en
dc.date.accessioned2015-11-24T19:12:01Z
dc.date.available2015-11-24T19:12:01Z
dc.identifier.issn0270-9139-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21000
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subject*Cytochrome P-450 Enzyme Systemen
dc.subjectDinoprostoneen
dc.subjectEpoprostenol/analysis/*biosynthesisen
dc.subjectFluorescent Antibody Techniqueen
dc.subjectHepatorenal Syndrome/*enzymology/urineen
dc.subjectHumansen
dc.subject*Intramolecular Oxidoreductasesen
dc.subjectKidney/analysis/*enzymologyen
dc.subjectKidney Diseases/*enzymologyen
dc.subjectKidney Failure, Chronic/metabolismen
dc.subjectMiddle Ageden
dc.subjectProstaglandin-Endoperoxide Synthases/*analysisen
dc.subjectProstaglandins E/urineen
dc.titleImmunohistochemical distribution of renal prostaglandin endoperoxide synthase and prostacyclin synthase: diminished endoperoxide synthase in the hepatorenal syndromeen
heal.abstractTo evaluate possible causes of the diminished prostaglandin production in advanced hepatorenal syndrome, prostaglandin endoperoxide synthase and prostacyclin synthase were localized and semiquantitated by immunofluorescence in postmortem, biopsy and nephrectomy renal tissues. In normal kidneys, antiprostacyclin synthase serum caused intense staining in peritubular capillaries, in the adjacent renal interstitial cells and in glomerular mesangial regions. Antiprostaglandin endoperoxide synthase serum caused staining of collecting duct epithelial cells, cells of the thin ascending limb and possibly glomerular mesangial cells. Prostacyclin synthase-positive staining was graded 5+ (scale of 0+ to 5+) in all kidney samples. Medullary collecting tubule prostaglandin endoperoxide synthase-positive staining was graded 4+ or 5+ in kidney samples from patients with acute tubular necrosis or acute tubulointerstitial nephritis and from patients with liver failure without the hepatorenal syndrome. However, prostaglandin endoperoxide synthase-positive staining was markedly diminished or absent (average 1+) in patients with the hepatorenal syndrome. These data suggest that loss of the medullary prostaglandin endoperoxide synthase is the cause of diminished urinary prostaglandin E2 excretion in the hepatorenal syndrome.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/3111964-
heal.identifier.secondaryhttp://onlinelibrary.wiley.com/store/10.1002/hep.1840070407/asset/1840070407_ftp.pdf?v=1&t=h0p330nw&s=942f5c42cf0f08c459e32550c5d40d14118a2833-
heal.journalNameHepatologyen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate1987-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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