Administration of recombinant human erythropoietin in patients with gynecological cancer before radical surgery
Φόρτωση...
Ημερομηνία
Συγγραφείς
Dousias, V.
Stefos, T.
Navrozoglou, I.
Staikos, I.
Ditto, A.
Paraskevaidis, E.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Clin Exp Obstet Gynecol
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
The purpose of this prospective study was to investigate the efficacy of preoperative administration of recombinant human erythropoietin in patients with gynecological cancer. METHODS: The study included 38 women with gynecological cancer who were divided randomly in two groups. Study group A included 20 women with gynecological cancer who received recombinant human erythropoietin (rHuEPO) plus iron supplementation for ten days before surgery and five days postoperatively. Group B (controls) included 18 patients who received only iron supplementation for the same time period. Blood samples were obtained on days -10, -3, 0, +3, +5, +10. RESULTS: The mean hemoglobin level was significantly higher in group A than in group B on the day of the operation and remained significantly higher postoperatively while an inverse relationship was observed for mean ferritin values in the two groups. CONCLUSION: Preoperative administration of rHuEPO in patients with gynecological cancer seems to be effective in the blood management of these patients.
Περιγραφή
Λέξεις-κλειδιά
Adult, Aged, Confidence Intervals, Dose-Response Relationship, Drug, Drug Administration Schedule, Erythropoietin/*administration & dosage, Female, Follow-Up Studies, Genital Neoplasms, Female/*drug therapy/mortality/pathology/*surgery, Gynecologic Surgical Procedures/*methods/mortality, Humans, Iron Compounds/*administration & dosage, Middle Aged, Neoplasm Staging, Preoperative Care, Probability, Prospective Studies, Recombinant Proteins, Reference Values, Risk Assessment, Survival Analysis, Treatment Outcome
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/16108399
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής