Administration of recombinant human erythropoietin in patients with gynecological cancer before radical surgery

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dc.contributor.authorDousias, V.en
dc.contributor.authorStefos, T.en
dc.contributor.authorNavrozoglou, I.en
dc.contributor.authorStaikos, I.en
dc.contributor.authorDitto, A.en
dc.contributor.authorParaskevaidis, E.en
dc.date.accessioned2015-11-24T19:37:28Z
dc.date.available2015-11-24T19:37:28Z
dc.identifier.issn0390-6663-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/24034
dc.rightsDefault Licence-
dc.subjectAdulten
dc.subjectAgeden
dc.subjectConfidence Intervalsen
dc.subjectDose-Response Relationship, Drugen
dc.subjectDrug Administration Scheduleen
dc.subjectErythropoietin/*administration & dosageen
dc.subjectFemaleen
dc.subjectFollow-Up Studiesen
dc.subjectGenital Neoplasms, Female/*drug therapy/mortality/pathology/*surgeryen
dc.subjectGynecologic Surgical Procedures/*methods/mortalityen
dc.subjectHumansen
dc.subjectIron Compounds/*administration & dosageen
dc.subjectMiddle Ageden
dc.subjectNeoplasm Stagingen
dc.subjectPreoperative Careen
dc.subjectProbabilityen
dc.subjectProspective Studiesen
dc.subjectRecombinant Proteinsen
dc.subjectReference Valuesen
dc.subjectRisk Assessmenten
dc.subjectSurvival Analysisen
dc.subjectTreatment Outcomeen
dc.titleAdministration of recombinant human erythropoietin in patients with gynecological cancer before radical surgeryen
heal.abstractThe purpose of this prospective study was to investigate the efficacy of preoperative administration of recombinant human erythropoietin in patients with gynecological cancer. METHODS: The study included 38 women with gynecological cancer who were divided randomly in two groups. Study group A included 20 women with gynecological cancer who received recombinant human erythropoietin (rHuEPO) plus iron supplementation for ten days before surgery and five days postoperatively. Group B (controls) included 18 patients who received only iron supplementation for the same time period. Blood samples were obtained on days -10, -3, 0, +3, +5, +10. RESULTS: The mean hemoglobin level was significantly higher in group A than in group B on the day of the operation and remained significantly higher postoperatively while an inverse relationship was observed for mean ferritin values in the two groups. CONCLUSION: Preoperative administration of rHuEPO in patients with gynecological cancer seems to be effective in the blood management of these patients.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/16108399-
heal.journalNameClin Exp Obstet Gynecolen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2005-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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