Antitumour and toxic effects on Wistar rats of two new platinum complexes
Φόρτωση...
Ημερομηνία
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Clin Invest
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Cancer chemotherapy in humans based on metal complexes started at the clinical level in the late 1970s with the use of cisplatin, which forms intra-strand cross-links with DNA. METHODS: Two new platinum complexes of cis-geometry with the amino acids inosine (ino) and l-alanine (ala), Pt(ino)2Cl2 and cis-[Pt(NH3)2(ala)](NO3), respectively, were synthesized and pure samples were obtained by means of flash chromatography. These complexes were tested on benzo(a)pyrene-induced tumours in Wistar rats to detect their antitumour and toxic effects. RESULTS: There was a statistically significant prolongation of the mean survival time of the animals in the two groups tested (272 +/- 18 days and 246 +/- 26 days, respectively) compared to the control group (195 +/- 22 days) (P < 0.001). Toxic effects included a decrease in leucocyte cell count, mild haemolysis, mild haematuria, mild hepatotoxicity, elevated body temperature and hair loss. All of these effects were reversible after drug discontinuation. CONCLUSIONS: The two new platinum complexes described here appear to have an effective antitumour activity without severe toxicity when tested on Wistar rats.
Περιγραφή
Λέξεις-κλειδιά
Animals, Antineoplastic Agents/*pharmacology/*toxicity, Benzo(a)pyrene/toxicity, Hematuria/chemically induced, Hemolysis/drug effects, Humans, Leukopenia/chemically induced, Liver/drug effects, Male, Organoplatinum Compounds/*pharmacology/*toxicity, Rats, Rats, Wistar, Sarcoma, Experimental/chemically induced/drug therapy/pathology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/11895460
http://onlinelibrary.wiley.com/store/10.1046/j.1365-2362.2002.00932.x/asset/j.1365-2362.2002.00932.x.pdf?v=1&t=h0c6vjwg&s=20b06116cbdd1d04515b2be616b69c656df84f20
http://onlinelibrary.wiley.com/store/10.1046/j.1365-2362.2002.00932.x/asset/j.1365-2362.2002.00932.x.pdf?v=1&t=h0c6vjwg&s=20b06116cbdd1d04515b2be616b69c656df84f20
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής