Antitumour and toxic effects on Wistar rats of two new platinum complexes
Φόρτωση...
Ημερομηνία
Συγγραφείς
Charalabopoulos, K.
Karkabounas, S.
Ioachim, E.
Papalimneou, V.
Syrigos, K.
Evangelou, A.
Agnantis, N.
Hadjiliadis, N.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Eur J Clin Invest
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
BACKGROUND: Cancer chemotherapy in humans based on metal complexes started at the clinical level in the late 1970s with the use of cisplatin, which forms intra-strand cross-links with DNA. METHODS: Two new platinum complexes of cis-geometry with the amino acids inosine (ino) and l-alanine (ala), Pt(ino)2Cl2 and cis-[Pt(NH3)2(ala)](NO3), respectively, were synthesized and pure samples were obtained by means of flash chromatography. These complexes were tested on benzo(a)pyrene-induced tumours in Wistar rats to detect their antitumour and toxic effects. RESULTS: There was a statistically significant prolongation of the mean survival time of the animals in the two groups tested (272 +/- 18 days and 246 +/- 26 days, respectively) compared to the control group (195 +/- 22 days) (P < 0.001). Toxic effects included a decrease in leucocyte cell count, mild haemolysis, mild haematuria, mild hepatotoxicity, elevated body temperature and hair loss. All of these effects were reversible after drug discontinuation. CONCLUSIONS: The two new platinum complexes described here appear to have an effective antitumour activity without severe toxicity when tested on Wistar rats.
Περιγραφή
Λέξεις-κλειδιά
Animals, Antineoplastic Agents/*pharmacology/*toxicity, Benzo(a)pyrene/toxicity, Hematuria/chemically induced, Hemolysis/drug effects, Humans, Leukopenia/chemically induced, Liver/drug effects, Male, Organoplatinum Compounds/*pharmacology/*toxicity, Rats, Rats, Wistar, Sarcoma, Experimental/chemically induced/drug therapy/pathology
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
http://www.ncbi.nlm.nih.gov/pubmed/11895460
http://onlinelibrary.wiley.com/store/10.1046/j.1365-2362.2002.00932.x/asset/j.1365-2362.2002.00932.x.pdf?v=1&t=h0c6vjwg&s=20b06116cbdd1d04515b2be616b69c656df84f20
http://onlinelibrary.wiley.com/store/10.1046/j.1365-2362.2002.00932.x/asset/j.1365-2362.2002.00932.x.pdf?v=1&t=h0c6vjwg&s=20b06116cbdd1d04515b2be616b69c656df84f20
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής