Antitumour and toxic effects on Wistar rats of two new platinum complexes
| dc.contributor.author | Charalabopoulos, K. | en |
| dc.contributor.author | Karkabounas, S. | en |
| dc.contributor.author | Ioachim, E. | en |
| dc.contributor.author | Papalimneou, V. | en |
| dc.contributor.author | Syrigos, K. | en |
| dc.contributor.author | Evangelou, A. | en |
| dc.contributor.author | Agnantis, N. | en |
| dc.contributor.author | Hadjiliadis, N. | en |
| dc.date.accessioned | 2015-11-24T19:35:51Z | |
| dc.date.available | 2015-11-24T19:35:51Z | |
| dc.identifier.issn | 0014-2972 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/23763 | |
| dc.rights | Default Licence | - |
| dc.subject | Animals | en |
| dc.subject | Antineoplastic Agents/*pharmacology/*toxicity | en |
| dc.subject | Benzo(a)pyrene/toxicity | en |
| dc.subject | Hematuria/chemically induced | en |
| dc.subject | Hemolysis/drug effects | en |
| dc.subject | Humans | en |
| dc.subject | Leukopenia/chemically induced | en |
| dc.subject | Liver/drug effects | en |
| dc.subject | Male | en |
| dc.subject | Organoplatinum Compounds/*pharmacology/*toxicity | en |
| dc.subject | Rats | en |
| dc.subject | Rats, Wistar | en |
| dc.subject | Sarcoma, Experimental/chemically induced/drug therapy/pathology | en |
| dc.title | Antitumour and toxic effects on Wistar rats of two new platinum complexes | en |
| heal.abstract | BACKGROUND: Cancer chemotherapy in humans based on metal complexes started at the clinical level in the late 1970s with the use of cisplatin, which forms intra-strand cross-links with DNA. METHODS: Two new platinum complexes of cis-geometry with the amino acids inosine (ino) and l-alanine (ala), Pt(ino)2Cl2 and cis-[Pt(NH3)2(ala)](NO3), respectively, were synthesized and pure samples were obtained by means of flash chromatography. These complexes were tested on benzo(a)pyrene-induced tumours in Wistar rats to detect their antitumour and toxic effects. RESULTS: There was a statistically significant prolongation of the mean survival time of the animals in the two groups tested (272 +/- 18 days and 246 +/- 26 days, respectively) compared to the control group (195 +/- 22 days) (P < 0.001). Toxic effects included a decrease in leucocyte cell count, mild haemolysis, mild haematuria, mild hepatotoxicity, elevated body temperature and hair loss. All of these effects were reversible after drug discontinuation. CONCLUSIONS: The two new platinum complexes described here appear to have an effective antitumour activity without severe toxicity when tested on Wistar rats. | en |
| heal.access | campus | - |
| heal.fullTextAvailability | TRUE | - |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/11895460 | - |
| heal.identifier.secondary | http://onlinelibrary.wiley.com/store/10.1046/j.1365-2362.2002.00932.x/asset/j.1365-2362.2002.00932.x.pdf?v=1&t=h0c6vjwg&s=20b06116cbdd1d04515b2be616b69c656df84f20 | - |
| heal.journalName | Eur J Clin Invest | en |
| heal.journalType | peer-reviewed | - |
| heal.language | en | - |
| heal.publicationDate | 2002 | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.type | journalArticle | - |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.type.en | Journal article | en |
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