Evaluation of meningioma aggressiveness by Tc-99m-Tetrofosmin SPECT
Φόρτωση...
Ημερομηνία
Συγγραφείς
Alexiou, G. A.
Vartholomatos, G.
Tsiouris, S.
Papadopoulos, A.
Kyritsis, A. P.
Polyzoidis, K. S.
Voulgaris, S.
Fotopoulos, A. D.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer-reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Clin Neurol Neurosurg
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Objectives: Although meningiomas usually have a benign clinical course, atypical and malignant types of this brain tumor are associated with high recurrence rates and poor outcome; thus, DNA ploidy and S-phase-as determined by DNA flow cytometry-are useful indicators of their biological behavior. Brain single-photon emission computed tomography (SPECT) has been suggested as a potentially useful modality for the metabolic assessment of various brain tumors. This study evaluated whether Tc-99m-Tetrofosmin (Tc-99m-TF) uptake correlates with meningioma proliferative activity, as assessed by flow cytometry analysis. Patients and methods: Ten consecutive patients (3 males, 7 females, mean age 64.6 years) with a diagnosis of a symptomatic intracranial. meningioma, planned to undergo surgery, were studied. Brain SPECT by Tc-99m-TF was performed within a week prior to surgical excision and flow cytometric analysis was performed in the excised tissue. Tumoral radiotracer accumulation was first assessed visually. Semiquantitative image analysis was also performed, by calculating the lesion-to-normal (L/N) uptake ratio. Results: Benign meningiomas were diagnosed in 8/10 cases, the remaining 2/10 patients had anaplastic lesions. DNA aneuploidy was found in 2 lesions, the remaining tumors were diploid. There was a significant correlation between tracer uptake and the percentage of the cell fraction on S-phase (r=0.733, P=0.05). There was also a positive correlation between tracer uptake and the level of aneuploidy and tumor grade. Conclusion: These results imply that Tc-99m-TF brain SPECT may have the ability to discriminate benign meningiomas from malignant meningiomas pre-operatively, the tracer uptake being a likely indicator of their proliferative activity. (c) 2008 Elsevier B.V. All rights reserved.
Περιγραφή
Λέξεις-κλειδιά
meningioma, spect, tc-99m-tetrofosmin, flow cytometry, intracranial meningiomas, recurrence, DNA
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000258368100001
http://ac.els-cdn.com/S0303846708001157/1-s2.0-S0303846708001157-main.pdf?_tid=ade43354fc7ef2dcf0872d6b88d1c518&acdnat=1332758525_b4244b24998431f124d5bdb3e75966a1
http://ac.els-cdn.com/S0303846708001157/1-s2.0-S0303846708001157-main.pdf?_tid=ade43354fc7ef2dcf0872d6b88d1c518&acdnat=1332758525_b4244b24998431f124d5bdb3e75966a1
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής