Evaluation of meningioma aggressiveness by Tc-99m-Tetrofosmin SPECT

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dc.contributor.authorAlexiou, G. A.en
dc.contributor.authorVartholomatos, G.en
dc.contributor.authorTsiouris, S.en
dc.contributor.authorPapadopoulos, A.en
dc.contributor.authorKyritsis, A. P.en
dc.contributor.authorPolyzoidis, K. S.en
dc.contributor.authorVoulgaris, S.en
dc.contributor.authorFotopoulos, A. D.en
dc.date.accessioned2015-11-24T19:17:45Z
dc.date.available2015-11-24T19:17:45Z
dc.identifier.issn0303-8467-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/21806
dc.rightsDefault Licence-
dc.subjectmeningiomaen
dc.subjectspecten
dc.subjecttc-99m-tetrofosminen
dc.subjectflow cytometryen
dc.subjectintracranial meningiomasen
dc.subjectrecurrenceen
dc.subjectDNAen
dc.titleEvaluation of meningioma aggressiveness by Tc-99m-Tetrofosmin SPECTen
heal.abstractObjectives: Although meningiomas usually have a benign clinical course, atypical and malignant types of this brain tumor are associated with high recurrence rates and poor outcome; thus, DNA ploidy and S-phase-as determined by DNA flow cytometry-are useful indicators of their biological behavior. Brain single-photon emission computed tomography (SPECT) has been suggested as a potentially useful modality for the metabolic assessment of various brain tumors. This study evaluated whether Tc-99m-Tetrofosmin (Tc-99m-TF) uptake correlates with meningioma proliferative activity, as assessed by flow cytometry analysis. Patients and methods: Ten consecutive patients (3 males, 7 females, mean age 64.6 years) with a diagnosis of a symptomatic intracranial. meningioma, planned to undergo surgery, were studied. Brain SPECT by Tc-99m-TF was performed within a week prior to surgical excision and flow cytometric analysis was performed in the excised tissue. Tumoral radiotracer accumulation was first assessed visually. Semiquantitative image analysis was also performed, by calculating the lesion-to-normal (L/N) uptake ratio. Results: Benign meningiomas were diagnosed in 8/10 cases, the remaining 2/10 patients had anaplastic lesions. DNA aneuploidy was found in 2 lesions, the remaining tumors were diploid. There was a significant correlation between tracer uptake and the percentage of the cell fraction on S-phase (r=0.733, P=0.05). There was also a positive correlation between tracer uptake and the level of aneuploidy and tumor grade. Conclusion: These results imply that Tc-99m-TF brain SPECT may have the ability to discriminate benign meningiomas from malignant meningiomas pre-operatively, the tracer uptake being a likely indicator of their proliferative activity. (c) 2008 Elsevier B.V. All rights reserved.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.clineuro.2008.03.016-
heal.identifier.secondary<Go to ISI>://000258368100001-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0303846708001157/1-s2.0-S0303846708001157-main.pdf?_tid=ade43354fc7ef2dcf0872d6b88d1c518&acdnat=1332758525_b4244b24998431f124d5bdb3e75966a1-
heal.journalNameClin Neurol Neurosurgen
heal.journalTypepeer-reviewed-
heal.languageen-
heal.publicationDate2008-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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