Effect of paraoxonase 1 polymorphisms on the response of lipids and lipoprotein-associated enzymes to treatment with fluvastatin
Φόρτωση...
Ημερομηνία
Συγγραφείς
Christidis, D. S.
Liberopoulos, E. N.
Kakafika, A. I.
Miltiadous, G. A.
Liamis, G. L.
Kakaidi, B.
Tselepis, A. D.
Cariolou, M. A.
Elisaf, M. S.
Τίτλος Εφημερίδας
Περιοδικό ISSN
Τίτλος τόμου
Εκδότης
Περίληψη
Τύπος
Είδος δημοσίευσης σε συνέδριο
Είδος περιοδικού
peer reviewed
Είδος εκπαιδευτικού υλικού
Όνομα συνεδρίου
Όνομα περιοδικού
Arch Med Res
Όνομα βιβλίου
Σειρά βιβλίου
Έκδοση βιβλίου
Συμπληρωματικός/δευτερεύων τίτλος
Περιγραφή
Background. Decreased paraoxonase 1 (PON1) and increased total serum lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activities are suggested to be risk factors for vascular disease. Common PON1 genetic polymorphisms (Q192R and L55M) significantly affect PON1 activity and may also influence high-density lipoprotein (HDL)-associated Lp-PLA(2) activity. However, little is known about the possible effect of PON1 common genetic polymorphisms on the response of lipids as well as PON1 and Lp-PLA(2) activities to treatment with statins. Methods. Two hundred two hypercholesterolemic patients were treated with fluvastatin 40 mg/day. Fasting serum lipids, Q192R and L55M PON1 polymorphisms as well as PON1 and Lp-PLA(2) (total serum and HDL-associated) activities were determined before and after 6 months of treatment. Results. Fluvastatin treatment did not affect HDL-cholesterol or apolipoprotein (apo) AI but resulted in significant decreases in total cholesterol, triglycerides, low-density lipoprotein-cholesterol, apo B and apo E, as well as total serum Lp-PLA(2) activity. In contrast, PON1 activity significantly increased. None of these changes was influenced by Q192R or L55M PON1 polymorphisms. Overall, HDL-Lp-PLA(2) did not change but L55M polymorphism significantly influenced its response to fluvastatin. Specifically, LL homozygotes experienced a significant increase, while M carriers (LM or MM) experienced a non-significant decrease in HDL-Lp-PLA(2) activity (p = 0.030 between groups). Conclusions. Q192R and L55M PON1 polymorphisms did not affect the response of lipids, PON1 and total serum Lp-PLA(2) to treatment with a statin. However, L55M PON1 polymorphism significantly modulated the response of HDL-Lp-PLA(2). It should be noted that this is an association study and therefore provides no proof but only indication that PON1 may also exert Lp-PLA(2) activity in HDL. (C) 2007 IMSS. Published by Elsevier Inc.
Περιγραφή
Λέξεις-κλειδιά
paraoxonase, polymorphism, lipoprotein-associated phospholipase a(2), platelet-activating factor acetylhydrolase, fluvastatin, lipids, platelet-activating-factor, coronary-heart-disease, c-reactive protein, middle-aged men, density-lipoprotein, serum paraoxonase, factor-acetylhydrolase, phospholipase a(2), plasma-lipoproteins, cardiovascular-disease
Θεματική κατηγορία
Παραπομπή
Σύνδεσμος
<Go to ISI>://000245930700007
http://ac.els-cdn.com/S0188440907000367/1-s2.0-S0188440907000367-main.pdf?_tid=4349964eba4f4306b5f088bc6b5046ce&acdnat=1333110993_a2c1a859da84b1283703dcaedc9276ef
http://ac.els-cdn.com/S0188440907000367/1-s2.0-S0188440907000367-main.pdf?_tid=4349964eba4f4306b5f088bc6b5046ce&acdnat=1333110993_a2c1a859da84b1283703dcaedc9276ef
Γλώσσα
en
Εκδίδον τμήμα/τομέας
Όνομα επιβλέποντος
Εξεταστική επιτροπή
Γενική Περιγραφή / Σχόλια
Ίδρυμα και Σχολή/Τμήμα του υποβάλλοντος
Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας