Effect of paraoxonase 1 polymorphisms on the response of lipids and lipoprotein-associated enzymes to treatment with fluvastatin

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dc.contributor.authorChristidis, D. S.en
dc.contributor.authorLiberopoulos, E. N.en
dc.contributor.authorKakafika, A. I.en
dc.contributor.authorMiltiadous, G. A.en
dc.contributor.authorLiamis, G. L.en
dc.contributor.authorKakaidi, B.en
dc.contributor.authorTselepis, A. D.en
dc.contributor.authorCariolou, M. A.en
dc.contributor.authorElisaf, M. S.en
dc.date.accessioned2015-11-24T16:57:03Z
dc.date.available2015-11-24T16:57:03Z
dc.identifier.issn0188-4409-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/10529
dc.rightsDefault Licence-
dc.subjectparaoxonaseen
dc.subjectpolymorphismen
dc.subjectlipoprotein-associated phospholipase a(2)en
dc.subjectplatelet-activating factor acetylhydrolaseen
dc.subjectfluvastatinen
dc.subjectlipidsen
dc.subjectplatelet-activating-factoren
dc.subjectcoronary-heart-diseaseen
dc.subjectc-reactive proteinen
dc.subjectmiddle-aged menen
dc.subjectdensity-lipoproteinen
dc.subjectserum paraoxonaseen
dc.subjectfactor-acetylhydrolaseen
dc.subjectphospholipase a(2)en
dc.subjectplasma-lipoproteinsen
dc.subjectcardiovascular-diseaseen
dc.titleEffect of paraoxonase 1 polymorphisms on the response of lipids and lipoprotein-associated enzymes to treatment with fluvastatinen
heal.abstractBackground. Decreased paraoxonase 1 (PON1) and increased total serum lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activities are suggested to be risk factors for vascular disease. Common PON1 genetic polymorphisms (Q192R and L55M) significantly affect PON1 activity and may also influence high-density lipoprotein (HDL)-associated Lp-PLA(2) activity. However, little is known about the possible effect of PON1 common genetic polymorphisms on the response of lipids as well as PON1 and Lp-PLA(2) activities to treatment with statins. Methods. Two hundred two hypercholesterolemic patients were treated with fluvastatin 40 mg/day. Fasting serum lipids, Q192R and L55M PON1 polymorphisms as well as PON1 and Lp-PLA(2) (total serum and HDL-associated) activities were determined before and after 6 months of treatment. Results. Fluvastatin treatment did not affect HDL-cholesterol or apolipoprotein (apo) AI but resulted in significant decreases in total cholesterol, triglycerides, low-density lipoprotein-cholesterol, apo B and apo E, as well as total serum Lp-PLA(2) activity. In contrast, PON1 activity significantly increased. None of these changes was influenced by Q192R or L55M PON1 polymorphisms. Overall, HDL-Lp-PLA(2) did not change but L55M polymorphism significantly influenced its response to fluvastatin. Specifically, LL homozygotes experienced a significant increase, while M carriers (LM or MM) experienced a non-significant decrease in HDL-Lp-PLA(2) activity (p = 0.030 between groups). Conclusions. Q192R and L55M PON1 polymorphisms did not affect the response of lipids, PON1 and total serum Lp-PLA(2) to treatment with a statin. However, L55M PON1 polymorphism significantly modulated the response of HDL-Lp-PLA(2). It should be noted that this is an association study and therefore provides no proof but only indication that PON1 may also exert Lp-PLA(2) activity in HDL. (C) 2007 IMSS. Published by Elsevier Inc.en
heal.accesscampus-
heal.fullTextAvailabilityTRUE-
heal.identifier.primaryDOI 10.1016/j.arcmed.2007.01.006-
heal.identifier.secondary<Go to ISI>://000245930700007-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0188440907000367/1-s2.0-S0188440907000367-main.pdf?_tid=4349964eba4f4306b5f088bc6b5046ce&acdnat=1333110993_a2c1a859da84b1283703dcaedc9276ef-
heal.journalNameArch Med Resen
heal.journalTypepeer reviewed-
heal.languageen-
heal.publicationDate2007-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.typejournalArticle-
heal.type.elΆρθρο Περιοδικούel
heal.type.enJournal articleen

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